| Reactions and Genes | BHIS with Chlorpromazine 0.2 mM |
|---|
| remove |
Beta-glucuronidase:
a β-D-glucuronide + H2O→D-glucopyranuronate + an alcohol (EC 3.2.1.31) |
| No genes |
Galactarate dehydratase:
galactarate→5-dehydro-4-deoxy-D-glucarate + H2O (EC 4.2.1.42) |
| No genes |
Glucarate dehydratase:
D-glucarate→5-dehydro-4-deoxy-D-glucarate + H2O (EC 4.2.1.40) |
| No genes |
Uronate dehydrogenase:
β-D-glucuronate + NAD+→D-glucaro-1,5-lactone + NADH + H+ (EC 1.1.1.203) |
| No genes |
| D-galactopyranuronate→aldehydo-D-galacturonate (spontaneous) |
| No genes |
| 4-deoxy-L-threo-hex-4-enopyranuronate→5-dehydro-4-deoxy-D-glucuronate (EC 4.2.99.25) |
| BT3081 | +0.1 |
Uronate dehydrogenase:
β-D-galacturonate + NAD+→D-galactaro-1,5-lactone + NADH + H+ (EC 1.1.1.203) |
| No genes |
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase:
5-dehydro-4-deoxy-D-glucuronate→3-deoxy-D-glycero-2,5-hexodiulosonate (EC 5.3.1.17) |
| BT3231 | -1.5 |
| BT4106 | +0.2 |
Glucuronate isomerase:
aldehydo-D-galacturonate→D-tagaturonate (EC 5.3.1.12) |
| BT_0823 | -0.4 |
2-dehydro-3-deoxyglucarate aldolase:
5-dehydro-4-deoxy-D-glucarate→(2R)-tartronate semialdehyde + pyruvate (EC 4.1.2.20) |
| No genes |
| aldehydo-D-galacturonate + NADPH + H+→L-galactonate + NADP+ (EC 1.1.1.365) |
| No genes |
| D-glucopyranuronate→aldehydo-D-glucuronate (spontaneous) |
| No genes |
| D-galactaro-1,5-lactone→D-galactaro-1,4-lactone (EC 5.4.1.4) |
| No genes |
| D-glucaro-1,5-lactone→D-glucaro-1,4-lactone (spontaneous) (EC 5.4.1.4) |
| No genes |
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (in reverse):
3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H+→2-dehydro-3-deoxy-D-gluconate + NAD+ (EC 1.1.1.127) |
| BT3232 | +0.1 |
Tagaturonate reductase (in reverse):
D-tagaturonate + NADH + H+→D-altronate + NAD+ (EC 1.1.1.58) |
| BT0825 | +0.1 |
Glucuronate isomerase:
aldehydo-D-glucuronate→D-fructuronate (EC 5.3.1.12) |
| BT_0823 | -0.4 |
| L-galactonate→2-dehydro-3-deoxy-L-galactonate + H2O (EC 4.2.1.146) |
| No genes |
| D-galactaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27) |
| No genes |
| D-glucaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27) |
| No genes |
2-hydroxy-3-oxopropionate reductase (in reverse):
(2R)-tartronate semialdehyde + NAD(P)H + H+→D-glycerate + NAD(P)+ (EC 1.1.1.60) |
| No genes |
5-dehydro-4-deoxyglucarate dehydratase:
5-dehydro-4-deoxy-D-glucarate + H+→2,5-dioxopentanoate + CO2 + H2O (EC 4.2.1.41) |
| No genes |
Altronate dehydratase:
D-altronate→2-dehydro-3-deoxy-D-gluconate + H2O (EC 4.2.1.7) |
| BT0486 | +0.1 |
| D-glycerate + ATP→2-phospho-D-glycerate + ADP + H+ (EC 2.7.1.165) |
| BT1437 | -0.2 |
Fructuronate reductase (in reverse):
D-fructuronate + NADH + H+→D-mannonate + NAD+ (EC 1.1.1.57) |
| BT0130 | +0.4 |
| BT1433 | +0.1 |
| 2-dehydro-3-deoxy-L-galactonate→L-glyceraldehyde + pyruvate (EC 4.1.2.54) |
| No genes |
2,5-dioxovalerate dehydrogenase:
2,5-dioxopentanoate + NADP+ + H2O→2-oxoglutarate + NADPH + 2 H+ (EC 1.2.1.26) |
| No genes |
Mannonate dehydratase:
D-mannonate→2-dehydro-3-deoxy-D-gluconate + H2O (EC 4.2.1.8) |
| BT0129 | -0.2 |
| BT1432 | -0.2 |
| L-glyceraldehyde + NADPH + H+→glycerol + NADP+ (EC 1.1.1.372) |
| No genes |
| 2-dehydro-3-deoxy-D-gluconate + ATP→2-dehydro-3-deoxy-D-gluconate 6-phosphate + ADP + H+ (EC 2.7.1.178; 2.7.1.45) |
| BT0488 | N.D. |
2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate (EC 4.1.2.14; 4.1.2.55) |
| BT0489 | N.D. |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information