MetaCyc Pathway: superpathway of phenylethylamine degradation in Phaeobacter inhibens DSM 17395

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Reactions and Genes m.b. Fusidic 0.0002 mg/ml
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Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)
No genes
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
No genes
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
PGA1_c26800 +0.1
PGA1_c32550 -0.1
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
PGA1_c04040 +0.1
PGA1_c04060 -0.0
PGA1_c04070 +0.0
PGA1_c04080 -0.1
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
PGA1_c16990 -2.7
PGA1_c26820 +0.2
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
No genes
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
No genes
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→(2E)-5-carboxy-2-pentenoyl-CoA + acetyl-CoA (EC 2.3.1.223)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
PGA1_c12020 +0.2
PGA1_c14440 +0.2
PGA1_c15660 +0.1
PGA1_c16990 -2.7
PGA1_c17350 +0.6
PGA1_c22740 -0.1
PGA1_c23460 -0.2
PGA1_c23920 -0.2
PGA1_c26820 +0.2
PGA1_c33450 +0.1
PGA1_c34200 +0.0
PGA1_c36500 N.D.
PGA1_262p01540 -0.0
PGA1_262p01850 -0.1
PGA1_262p01980 +0.1
PGA1_c04110 +0.3
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
PGA1_c11320 -0.2
PGA1_c12020 +0.2
PGA1_c22740 -0.1
PGA1_c04110 +0.3
PGA1_c08420 +0.3
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
PGA1_c04090 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information