MetaCyc Pathway: superpathway of purine nucleotide salvage in Klebsiella michiganensis M5al

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Reactions and Genes Cobalt chloride 0.5 mM
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Adenosine kinase:
adenosine + ATP→AMP + ADP + H+ (EC 2.7.1.20)
No genes
Purine-nucleoside phosphorylase:
adenosine + phosphate→adenine + α-D-ribose-1-phosphate (EC 2.4.2.1)
BWI76_RS01010 -0.0
BWI76_RS04145 +0.2
BWI76_RS06200 +0.1
BWI76_RS11440 +0.1
BWI76_RS20605 -0.0
BWI76_RS21445 -1.5
Adenylosuccinate synthase:
IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)
BWI76_RS02565 N.D.
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
BWI76_RS21030 N.D.
Purine-nucleoside phosphorylase:
guanosine + phosphate→guanine + α-D-ribose-1-phosphate (EC 2.4.2.1; 2.4.2.15)
BWI76_RS01010 -0.0
BWI76_RS04145 +0.2
BWI76_RS06200 +0.1
BWI76_RS11440 +0.1
BWI76_RS20605 -0.0
Adenine phosphoribosyltransferase (in reverse):
adenine + 5-phospho-α-D-ribose 1-diphosphate→AMP + diphosphate (EC 2.4.2.7)
BWI76_RS06815 -0.3
Adenylosuccinate lyase:
adenylosuccinate→AMP + fumarate (EC 4.3.2.2)
BWI76_RS11305 N.D.
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
BWI76_RS14000 +0.2
BWI76_RS21025 N.D.
Hypoxanthine phosphoribosyltransferase (in reverse):
guanine + 5-phospho-α-D-ribose 1-diphosphate→GMP + diphosphate (EC 2.4.2.8)
BWI76_RS04955 -1.9
BWI76_RS05545 N.D.
BWI76_RS06815 -0.3
Adenylate kinase:
AMP + ATP→2 ADP (EC 2.7.4.3)
BWI76_RS06840 N.D.
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
BWI76_RS02190 -0.4
BWI76_RS27420 N.D.
Ribonucleoside-diphosphate reductase (in reverse):
ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
BWI76_RS19940 N.D.
BWI76_RS19945 N.D.
BWI76_RS22050 -1.1
BWI76_RS22055 -1.6
BWI76_RS22060 -0.8
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
BWI76_RS06840 N.D.
BWI76_RS21100 +0.0
Nucleoside-diphosphate kinase:
dADP + ATP→ADP + dATP (EC 2.7.4.6)
BWI76_RS21100 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information