MetaCyc Pathway: pyrimidine deoxyribonucleotides biosynthesis from CTP in Klebsiella michiganensis M5al

Reactions and Genes	Cobalt chloride 0.5 mM
Nucleoside-triphosphatase: CTP + H2O→CDP + H+ + phosphate (EC 3.6.1.15; 3.6.1.5)
BWI76_RS24115	+0.3
Ribonucleoside-diphosphate reductase (in reverse): CDP + a reduced thioredoxin→dCDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
BWI76_RS19940	N.D.
BWI76_RS19945	N.D.
BWI76_RS22050	-1.1
BWI76_RS22055	-1.6
BWI76_RS22060	-0.8
Nucleoside-diphosphate kinase: dCDP + ATP→dCTP + ADP (EC 2.7.4.6)
BWI76_RS06840	N.D.
BWI76_RS21100	+0.0
Apyrase: dCDP + H2O→dCMP + H+ + phosphate (EC 3.6.1.5; 3.6.1.6)
No genes
dCMP deaminase: dCMP + H+ + H2O→dUMP + ammonium (EC 3.5.4.12)
No genes
Thymidylate synthase: dUMP + a 5,10-methylenetetrahydrofolate→dTMP + a 7,8-dihydrofolate (EC 2.1.1.45)
BWI76_RS14320	+0.0
T(2)-induced deoxynucleotide kinase: dTMP + ATP→dTDP + ADP (EC 2.7.4.12; 2.7.4.13; 2.7.4.9)
BWI76_RS11115	N.D.
Nucleoside-diphosphate kinase: dTDP + ATP→dTTP + ADP (EC 2.7.4.6)
BWI76_RS06840	N.D.
BWI76_RS21100	+0.0

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information