MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Klebsiella michiganensis M5al

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Reactions and Genes Cobalt chloride 0.5 mM
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
BWI76_RS08600 +0.2
BWI76_RS15085 +0.5
BWI76_RS17075 +2.6
BWI76_RS21480 +0.8
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
BWI76_RS26085 +7.0
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
BWI76_RS04645 +4.9
BWI76_RS22790 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
BWI76_RS01715 +0.3
BWI76_RS04655 -0.5
BWI76_RS06460 +0.7
BWI76_RS16935 -0.5
BWI76_RS25645 +3.4
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
BWI76_RS06185 -0.4
BWI76_RS26090 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
BWI76_RS09760 -0.9
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
BWI76_RS20435 -2.9
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
BWI76_RS21465 +0.2
BWI76_RS21475 +0.1
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
BWI76_RS21475 +0.1
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
BWI76_RS01925 +0.2
BWI76_RS03690 +0.3
BWI76_RS06660 -0.0
BWI76_RS06750 +0.0
BWI76_RS07560 +0.4
BWI76_RS07570 +0.6
BWI76_RS08675 +0.3
BWI76_RS09870 -0.4
BWI76_RS10245 -0.4
BWI76_RS12985 -2.4
BWI76_RS13400 +0.0
BWI76_RS18930 -0.3
BWI76_RS20205 +0.6
BWI76_RS22035 -0.5
BWI76_RS24235 -0.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information