MetaCyc Pathway: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass in Klebsiella michiganensis M5al

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Reactions and Genes Nickel (II) chloride 1.5 mM
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D-glucopyranose[out] + an [HPr protein]-Nπ-phospho-L-histidine[in]→D-glucopyranose 6-phosphate[in] + an [HPr]-L-histidine[in] (EC 2.7.1.199)
BWI76_RS01725 +0.2
BWI76_RS01730 +0.0
BWI76_RS11130 -0.0
BWI76_RS17890 +0.2
BWI76_RS17895 -0.1
BWI76_RS17900 -0.1
BWI76_RS20655 N.D.
Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
BWI76_RS01800 -4.1
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
BWI76_RS00530 -0.0
BWI76_RS00735 N.D.
BWI76_RS17175 N.D.
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
BWI76_RS00545 +0.0
BWI76_RS14880 -0.2
BWI76_RS19370 -1.7
BWI76_RS23975 N.D.
BWI76_RS27560 +0.5
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
BWI76_RS02815 -0.2
BWI76_RS06160 -0.0
BWI76_RS08660 +0.1
BWI76_RS27445 +0.0
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
BWI76_RS03100 +0.3
BWI76_RS27465 N.D.
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
BWI76_RS11505 N.D.
BWI76_RS12975 +0.4
BWI76_RS13215 -0.9
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
BWI76_RS23980 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
BWI76_RS04200 -0.2
BWI76_RS08605 -3.4
BWI76_RS13025 +0.2
BWI76_RS27230 +0.0
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
BWI76_RS08605 -3.4
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
BWI76_RS22790 N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
BWI76_RS16960 N.D.
BWI76_RS18115 +0.3
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
BWI76_RS17065 +0.7
pyruvate + coenzyme A + NAD+→acetyl-CoA + CO2 + NADH (EC 1.2.1.104)
BWI76_RS04880 N.D.
BWI76_RS04885 N.D.
BWI76_RS04890 N.D.
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
BWI76_RS08385 -2.0
BWI76_RS19140 +0.1
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9)
BWI76_RS01660 +0.2
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
BWI76_RS04910 N.D.
BWI76_RS11940 -1.2
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
BWI76_RS04910 N.D.
BWI76_RS11940 -1.2
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate (EC 4.1.3.1)
BWI76_RS01665 -0.3
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
BWI76_RS11330 N.D.
2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
BWI76_RS04890 N.D.
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
BWI76_RS08425 -0.9
BWI76_RS08430 -0.9
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
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Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
BWI76_RS08450 -0.1
BWI76_RS16115 -0.1
BWI76_RS16270 +0.2
BWI76_RS16275 +0.2
BWI76_RS16955 -0.9
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
BWI76_RS13830 +0.2
BWI76_RS16775 -0.5
BWI76_RS25420 +0.1
(S)-malate[in] + an electron-transfer quinone→oxaloacetate[in] + an electron-transfer quinol (EC 1.1.5.4)
BWI76_RS16065 -0.3
BWI76_RS19870 +0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information