MetaCyc Pathway: pyruvate fermentation to butanoate in Caulobacter crescentus NA1000

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Reactions and Genes PYE 30C survival rep2 28 days
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
CCNA_00075 -0.8
CCNA_00266 +0.2
CCNA_00544 +0.0
CCNA_00820 -0.2
CCNA_00938 +0.2
CCNA_01168 +1.0
CCNA_01499 +0.1
CCNA_02045 -0.2
CCNA_02490 -2.6
CCNA_03209 -0.7
CCNA_03575 +0.1
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
CCNA_00074 -1.2
CCNA_00752 -0.9
CCNA_01890 -0.2
CCNA_03293 -0.7
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
CCNA_00358 -0.2
CCNA_00401 +0.0
CCNA_01794 +0.3
CCNA_01890 -0.2
CCNA_01927 +0.1
CCNA_02484 -0.3
CCNA_02658 -0.9
CCNA_03180 -0.3
CCNA_03293 -0.7
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Phosphate butyryltransferase:
butanoyl-CoA + phosphate→butanoyl phosphate + coenzyme A (EC 2.3.1.19)
No genes
Branched-chain-fatty-acid kinase (in reverse):
butanoyl phosphate + ADP→butanoate + ATP (EC 2.7.2.14; 2.7.2.7)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information