MetaCyc Pathway: noradrenaline and adrenaline degradation in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Lomefloxacin 0.0002 mM
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Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf6N2E2_4632 -1.0
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
Pf6N2E2_4632 -1.0
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf6N2E2_4632 -1.0
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
Pf6N2E2_1380 N.D.
Pf6N2E2_1522 +0.1
Pf6N2E2_194 -0.1
Pf6N2E2_2802 -0.1
Pf6N2E2_3044 +0.2
Pf6N2E2_4819 +0.1
Pf6N2E2_5980 -0.1
Pf6N2E2_840 -0.0
Pf6N2E2_999 -0.1
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
Pf6N2E2_1381 -0.1
Pf6N2E2_1764 +0.1
Pf6N2E2_1854 +0.2
Pf6N2E2_1874 N.D.
Pf6N2E2_1878 -0.0
Pf6N2E2_1906 +0.1
Pf6N2E2_1919 +0.0
Pf6N2E2_225 +0.1
Pf6N2E2_3298 -0.2
Pf6N2E2_351 -0.2
Pf6N2E2_3582 +0.1
Pf6N2E2_4383 +0.3
Pf6N2E2_4964 +0.1
Pf6N2E2_4979 +0.0
Pf6N2E2_5476 +0.3
Pf6N2E2_935 -0.0
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
Pf6N2E2_4632 -1.0
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
Pf6N2E2_1380 N.D.
Pf6N2E2_1522 +0.1
Pf6N2E2_194 -0.1
Pf6N2E2_2802 -0.1
Pf6N2E2_3044 +0.2
Pf6N2E2_4819 +0.1
Pf6N2E2_5980 -0.1
Pf6N2E2_840 -0.0
Pf6N2E2_999 -0.1
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
Pf6N2E2_1381 -0.1
Pf6N2E2_1764 +0.1
Pf6N2E2_1854 +0.2
Pf6N2E2_1874 N.D.
Pf6N2E2_1878 -0.0
Pf6N2E2_1906 +0.1
Pf6N2E2_1919 +0.0
Pf6N2E2_225 +0.1
Pf6N2E2_3298 -0.2
Pf6N2E2_351 -0.2
Pf6N2E2_3582 +0.1
Pf6N2E2_4383 +0.3
Pf6N2E2_4964 +0.1
Pf6N2E2_4979 +0.0
Pf6N2E2_5476 +0.3
Pf6N2E2_935 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information