MetaCyc Pathway: superpathway of sulfate assimilation and cysteine biosynthesis in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Fusidic 0.4 mg/ml
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Phosphoglycerate dehydrogenase:
3-phospho-D-glycerate + NAD+→3-phosphooxypyruvate + NADH + H+ (EC 1.1.1.95)
Pf6N2E2_1079 -0.1
Pf6N2E2_2725 -1.9
Pf6N2E2_3246 N.D.
Pf6N2E2_372 +0.3
Pf6N2E2_3932 +0.0
Pf6N2E2_562 +0.2
Pf6N2E2_6020 -0.0
Sulfate adenylyltransferase:
sulfate + ATP + H+→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)
Pf6N2E2_5257 +0.3
Pf6N2E2_5258 +0.3
Adenylyl-sulfate kinase:
adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H+ (EC 2.7.1.25)
Pf6N2E2_3654 +0.4
Pf6N2E2_5258 +0.3
Phosphoserine transaminase (in reverse):
3-phosphooxypyruvate + L-glutamate→O-phospho-L-serine + 2-oxoglutarate (EC 2.6.1.52)
Pf6N2E2_2521 N.D.
Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse):
3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H+ (EC 1.8.4.8)
Pf6N2E2_6054 N.D.
Phosphoserine phosphatase:
O-phospho-L-serine + H2O→L-serine + phosphate (EC 3.1.3.3)
Pf6N2E2_1589 +0.0
Pf6N2E2_3630 +0.2
Pf6N2E2_3940 +0.1
Pf6N2E2_4563 -0.0
Pf6N2E2_5785 +0.4
Pf6N2E2_6055 -0.3
Serine O-acetyltransferase:
L-serine + acetyl-CoA→O-acetyl-L-serine + coenzyme A (EC 2.3.1.30)
Pf6N2E2_3191 +0.1
Sulfite reductase (NADPH) (in reverse):
sulfite + 3 NADPH + 5 H+→hydrogen sulfide + 3 NADP+ + 3 H2O (EC 1.8.1.2)
Pf6N2E2_1511 -0.2
Pf6N2E2_2073 -0.3
Pf6N2E2_3335 -0.1
Cysteine synthase:
O-acetyl-L-serine + hydrogen sulfide→L-cysteine + acetate + H+ (EC 2.5.1.47)
Pf6N2E2_2700 -0.0
Pf6N2E2_2936 -0.0
Pf6N2E2_3321 -0.4
Pf6N2E2_5721 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information