MetaCyc Pathway: superpathway of aromatic amino acid biosynthesis in Pseudomonas syringae pv. syringae B728a

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Reactions and Genes L-Malic (C)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
Psyr_2073 -0.4
Psyr_2900 +0.2
Psyr_3622 +0.1
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
Psyr_0409 N.D.
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
Psyr_1363 N.D.
Psyr_1482 +0.3
Psyr_4399 N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
Psyr_0025 -1.1
Psyr_2132 -0.2
Psyr_2418 -0.1
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
Psyr_0408 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
Psyr_0888 N.D.
Psyr_3644 -1.1
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
Psyr_1853 N.D.
Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
Psyr_4581 -5.3
Psyr_4609 -4.2
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
Psyr_3645 N.D.
Psyr_4818 N.D.
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
Psyr_1151 +0.1
Psyr_3645 N.D.
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
Psyr_3644 -1.1
Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)
Psyr_3172 +0.1
Psyr_4580 -4.3
Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)
Psyr_1663 -4.2
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
Psyr_0117 +0.1
Psyr_0230 -0.1
Psyr_1841 -0.1
Psyr_1973 -0.2
Psyr_2000 -0.1
Psyr_2910 -0.0
Psyr_3087 +0.3
Psyr_3615 +1.7
Psyr_4132 -3.7
Psyr_4325 -0.1
Psyr_4898 -1.4
Psyr_5056 -0.0
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
Psyr_0117 +0.1
Psyr_0230 -0.1
Psyr_1841 -0.1
Psyr_1973 -0.2
Psyr_2000 -0.1
Psyr_2910 -0.0
Psyr_3087 +0.3
Psyr_3615 +1.7
Psyr_4132 -3.7
Psyr_4325 -0.1
Psyr_4898 -1.4
Psyr_5056 -0.0
Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (EC 4.1.1.48)
Psyr_0756 +0.1
Psyr_4579 -0.4
Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)
Psyr_0033 -3.5
Psyr_0034 -3.1
indole + L-serine→L-tryptophan + H2O (EC 4.2.1.122; 4.2.1.20)
Psyr_0033 -3.5
Psyr_0034 -3.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information