MetaCyc Pathway: polyhydroxybutanoate biosynthesis in Mycobacterium tuberculosis H37Rv

Add experiment(s):


Reactions and Genes 7H9 with nitrite 1.5 mM; pH 5.5
remove
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
Rv0243 +0.1
Rv0859 N.D.
Rv0914c +0.4
Rv1074c -1.2
Rv1135A N.D.
Rv1323 -0.7
Rv1867 +0.4
Rv2790c +0.1
Rv3523 +0.1
Rv3546 -0.4
Rv3556c +0.5
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
No genes
(3R)-3-hydroxybutanoyl-CoA + poly-[(R)-3-hydroxybutanoate]→poly-[(R)-3-hydroxybutanoate] + coenzyme A (EC 2.3.1.304)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information