MetaCyc Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis IV in Klebsiella michiganensis M5al

Reactions and Genes	Cobalt chloride 0.5 mM
Nucleoside-triphosphatase: CTP + H2O→CDP + H+ + phosphate (EC 3.6.1.15; 3.6.1.5)
BWI76_RS24115	-0.8
Ribonucleoside-diphosphate reductase (in reverse): CDP + a reduced thioredoxin→dCDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
BWI76_RS19940	N.D.
BWI76_RS19945	N.D.
BWI76_RS22050	-1.9
BWI76_RS22055	-1.7
BWI76_RS22060	-0.8
Nucleoside-diphosphate kinase: dCDP + ATP→dCTP + ADP (EC 2.7.4.6)
BWI76_RS06840	N.D.
BWI76_RS21100	+0.5
dCTP deaminase (dUMP-forming): dCTP + 2 H2O→dUMP + ammonium + diphosphate (EC 3.5.4.30)
No genes
Thymidylate synthase: dUMP + 5,10-methylene-tetrahydromethanopterin→dTMP + 7,8-dihydromethanopterin (EC 2.1.1.45)
BWI76_RS14320	-0.2
T(2)-induced deoxynucleotide kinase: dTMP + ATP→dTDP + ADP (EC 2.7.4.12; 2.7.4.13; 2.7.4.9)
BWI76_RS11115	N.D.
Nucleoside-diphosphate kinase: dTDP + ATP→dTTP + ADP (EC 2.7.4.6)
BWI76_RS06840	N.D.
BWI76_RS21100	+0.5

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information