MetaCyc Pathway: superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) in Klebsiella michiganensis M5al

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Reactions and Genes Nickel (II) chloride 1.5 mM
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Nucleoside-triphosphatase:
CTP + H2O→CDP + H+ + phosphate (EC 3.6.1.15; 3.6.1.5)
BWI76_RS24115 +0.2
Ribonucleoside-diphosphate reductase (in reverse):
UDP + a reduced NrdH glutaredoxin-like protein→dUDP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)
BWI76_RS19940 N.D.
BWI76_RS19945 N.D.
BWI76_RS22055 -1.3
BWI76_RS22060 -1.2
CTP + formate + H+→dCTP + CO2 + H2O (EC 1.1.98.6)
BWI76_RS02935 +0.1
formate + UTP + H+→dUTP + CO2 + H2O (EC 1.1.98.6)
BWI76_RS02935 +0.1
Ribonucleoside-diphosphate reductase (in reverse):
UDP + a reduced thioredoxin→dUDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
BWI76_RS19940 N.D.
BWI76_RS19945 N.D.
BWI76_RS22050 -0.9
BWI76_RS22055 -1.3
BWI76_RS22060 -1.2
Ribonucleoside-diphosphate reductase (in reverse):
CDP + a reduced thioredoxin→dCDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
BWI76_RS19940 N.D.
BWI76_RS19945 N.D.
BWI76_RS22050 -0.9
BWI76_RS22055 -1.3
BWI76_RS22060 -1.2
Nucleoside-diphosphate kinase:
dUDP + ATP→dUTP + ADP (EC 2.7.4.6)
BWI76_RS21100 +0.2
Ribonucleoside-diphosphate reductase (in reverse):
CDP + a reduced NrdH glutaredoxin-like protein→dCDP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)
BWI76_RS19940 N.D.
BWI76_RS19945 N.D.
BWI76_RS22055 -1.3
BWI76_RS22060 -1.2
Nucleoside-diphosphate kinase:
dCDP + ATP→dCTP + ADP (EC 2.7.4.6)
BWI76_RS06840 N.D.
BWI76_RS21100 +0.2
dCTP deaminase:
dCTP + H+ + H2O→dUTP + ammonium (EC 3.5.4.13)
BWI76_RS19120 N.D.
dUTP diphosphatase:
dUTP + H2O→dUMP + diphosphate + H+ (EC 3.6.1.23; 3.6.1.9)
BWI76_RS20020 -0.0
BWI76_RS27375 N.D.
Thymidylate synthase:
dUMP + a 5,10-methylenetetrahydrofolate→dTMP + a 7,8-dihydrofolate (EC 2.1.1.45)
BWI76_RS14320 -0.7
T(2)-induced deoxynucleotide kinase:
dTMP + ATP→dTDP + ADP (EC 2.7.4.12; 2.7.4.13; 2.7.4.9)
BWI76_RS11115 N.D.
Nucleoside-diphosphate kinase:
dTDP + ATP→dTTP + ADP (EC 2.7.4.6)
BWI76_RS06840 N.D.
BWI76_RS21100 +0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information