MetaCyc Pathway: polymyxin resistance in Klebsiella michiganensis M5al

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Reactions and Genes Nickel (II) chloride 1.5 mM
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UDP-α-D-glucuronate + NAD+→UDP-β-L-threo-pentapyranos-4-ulose + CO2 + NADH (EC 1.1.1.305)
BWI76_RS26475 +1.4
UDP-β-L-threo-pentapyranos-4-ulose + L-glutamate→UDP-4-amino-4-deoxy-β-L-arabinopyranose + 2-oxoglutarate (EC 2.6.1.87; 2.6.1.92)
BWI76_RS26485 +0.8
UDP-4-amino-4-deoxy-β-L-arabinopyranose + an N10-formyltetrahydrofolate→UDP-4-deoxy-4-formamido-β-L-arabinopyranose + H+ + a tetrahydrofolate (EC 2.1.2.13)
BWI76_RS26475 +1.4
UDP-4-deoxy-4-formamido-β-L-arabinopyranose + di-trans,octa-cis-undecaprenyl phosphate→4-deoxy-4-formamido-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + UDP (EC 2.4.2.53)
BWI76_RS26480 +0.8
4-deoxy-4-formamido-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + H2O→4-amino-4-deoxy-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + formate
No genes
4-amino-4-deoxy-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate + α-D-Kdo-(2→4)-α-D-Kdo-(2→6)-lipid A (E. coli)→α-Kdo-(2→4)-α-Kdo-(2→6)-[P4'-α-L-ara4N]-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate (EC 2.4.2.43)
BWI76_RS26465 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information