MetaCyc Pathway: superpathway of adenosine nucleotides de novo biosynthesis II in Klebsiella michiganensis M5al

Reactions and Genes	Nickel (II) chloride 1.5 mM
Adenylosuccinate synthase: IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)
BWI76_RS02565	N.D.
Adenylosuccinate lyase: adenylosuccinate→AMP + fumarate (EC 4.3.2.2)
BWI76_RS11305	N.D.
Adenylate kinase: AMP + ATP→2 ADP (EC 2.7.4.3)
BWI76_RS06840	N.D.
Ribonucleoside-diphosphate reductase (in reverse): ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
BWI76_RS19940	N.D.
BWI76_RS19945	N.D.
BWI76_RS22050	-0.9
BWI76_RS22055	-1.3
BWI76_RS22060	-1.2
Ribonucleoside-diphosphate reductase (in reverse): ADP + a reduced NrdH glutaredoxin-like protein→dADP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)
BWI76_RS19940	N.D.
BWI76_RS19945	N.D.
BWI76_RS22055	-1.3
BWI76_RS22060	-1.2
Nucleoside-diphosphate kinase: dADP + ATP→ADP + dATP (EC 2.7.4.6)
BWI76_RS21100	+0.2
ATP + formate + H+→dATP + CO2 + H2O (EC 1.1.98.6)
BWI76_RS02935	+0.1

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information