MetaCyc Pathway: ketogenesis in Herbaspirillum seropedicae SmR1

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Reactions and Genes Carbon source Phenylacetic 5 mM
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
HSERO_RS01180 -0.3
HSERO_RS01265 -0.4
HSERO_RS04635 +0.4
HSERO_RS19070 -0.2
HSERO_RS19990 +0.1
HSERO_RS20030 +0.1
HSERO_RS20660 -4.9
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetyl-CoA + acetoacetate (EC 4.1.3.4)
HSERO_RS23475 -0.4
3-hydroxybutyrate dehydrogenase (in reverse):
acetoacetate + NADH + H+→(R)-3-hydroxybutanoate + NAD+ (EC 1.1.1.30)
HSERO_RS06265 -0.0
HSERO_RS17235 +0.1
HSERO_RS21160 +0.1
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information