MetaCyc Pathway: ureide biosynthesis in Klebsiella michiganensis M5al

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Reactions and Genes Inosine (N)
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IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
BWI76_RS21030 N.D.
5'-nucleotidase:
XMP + H2O→xanthosine + phosphate (EC 3.1.3.5)
BWI76_RS01930 +0.3
BWI76_RS03465 +0.1
BWI76_RS04095 +0.1
BWI76_RS06865 +0.0
BWI76_RS20210 +0.2
BWI76_RS22660 +0.2
Purine-nucleoside phosphorylase:
xanthosine + phosphate→xanthine + α-D-ribose-1-phosphate (EC 2.4.2.1)
BWI76_RS01010 -0.2
BWI76_RS04145 -1.2
BWI76_RS06200 -0.0
BWI76_RS11440 +0.1
BWI76_RS20605 +0.1
Xanthine dehydrogenase:
xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4)
BWI76_RS17570 -0.6
BWI76_RS17575 +0.1
Urate oxidase:
urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3)
BWI76_RS10540 -5.9
Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+ (EC 3.5.2.17)
BWI76_RS10515 N.D.
BWI76_RS17590 +0.1
(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97)
BWI76_RS10510 -5.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information