MetaCyc Pathway: urate conversion to allantoin I in Klebsiella michiganensis M5al

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Reactions and Genes Inosine (N)
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Urate oxidase:
urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide
(EC 1.7.3.3)
BWI76_RS10540 -5.9
Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+
(EC 3.5.2.17)
BWI76_RS10515 N.D.
BWI76_RS17590 +0.1
(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97)
BWI76_RS10510 -5.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information