MetaCyc Pathway: superpathway of L-citrulline metabolism in Klebsiella michiganensis M5al

Add experiment(s):


Reactions and Genes Inosine (N)
remove
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
BWI76_RS04465 -6.9
BWI76_RS04470 -6.9
BWI76_RS08180 -5.9
BWI76_RS08455 -0.2
BWI76_RS10250 +0.0
BWI76_RS10550 -1.5
BWI76_RS11445 +0.4
BWI76_RS11855 -5.6
BWI76_RS11860 -8.2
BWI76_RS14000 -0.0
BWI76_RS14505 -0.1
BWI76_RS14975 +0.2
BWI76_RS15200 -0.0
BWI76_RS17550 -0.2
BWI76_RS17865 +0.1
BWI76_RS20850 -0.1
BWI76_RS21025 N.D.
BWI76_RS21535 -0.1
BWI76_RS22795 N.D.
BWI76_RS25315 -5.3
BWI76_RS25320 -5.2
BWI76_RS26005 +0.2
Carbamoyl-phosphate synthase (ammonia):
ammonium + 2 ATP + hydrogen carbonate→carbamoyl phosphate + 2 ADP + 2 H+ + phosphate (EC 6.3.4.16)
No genes
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
BWI76_RS10795 +0.2
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
BWI76_RS05840 -6.9
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
BWI76_RS05835 -7.3
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
No genes
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
BWI76_RS03010 -5.0
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
BWI76_RS25115 -8.2
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
BWI76_RS00855 -7.2
Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
No genes
Nitric-oxide synthase:
2 L-arginine + 3 NADPH + 4 dioxygen + H+→2 L-citrulline + 3 NADP+ + 2 nitric oxide + 4 H2O (EC 1.14.13.39)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information