MetaCyc Pathway: L-tryptophan degradation III (eukaryotic) in Burkholderia phytofirmans PsJN

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Reactions and Genes 2-Deoxy-D-ribonic lithium salt (C)
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Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52)
BPHYT_RS16035 N.D.
Arylformamidase:
N-formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9)
BPHYT_RS09685 +0.1
BPHYT_RS16025 -0.2
Kynurenine 3-monooxygenase:
L-kynurenine + NADPH + dioxygen + H+→3-hydroxy-L-kynurenine + NADP+ + H2O (EC 1.14.13.9)
No genes
Kynureninase:
3-hydroxy-L-kynurenine + H2O→3-hydroxyanthranilate + L-alanine + H+ (EC 3.7.1.3)
BPHYT_RS07275 -0.2
BPHYT_RS16030 -0.0
3-hydroxyanthranilate 3,4-dioxygenase:
3-hydroxyanthranilate + dioxygen→2-amino-3-carboxymuconate-6-semialdehyde (EC 1.13.11.6)
BPHYT_RS07265 +0.6
Aminocarboxymuconate-semialdehyde decarboxylase:
2-amino-3-carboxymuconate-6-semialdehyde + H+→(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + CO2 (EC 4.1.1.45)
BPHYT_RS07270 N.D.
Aminomuconate-semialdehyde dehydrogenase:
(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + NAD+ + H2O→(2Z,4E)-2-aminomuconate + NADH + 2 H+ (EC 1.2.1.32)
BPHYT_RS07235 +0.6
2-aminomuconate deaminase:
(2Z,4E)-2-aminomuconate + H2O→(3E)-2-oxohex-3-enedioate + ammonium (EC 3.5.99.5)
BPHYT_RS07260 N.D.
(3E)-2-oxohex-3-enedioate + NADH + H+→2-oxoadipate + NAD+
No genes
2-oxoadipate + coenzyme A + NAD+→glutaryl-CoA + CO2 + NADH (EC 1.2.1.105)
No genes
glutaryl-CoA + an oxidized electron-transfer flavoprotein + H+→(E)-glutaconyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.6)
No genes
(E)-glutaconyl-CoA + H+→crotonyl-CoA + CO2 (EC 1.3.8.6)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
BPHYT_RS02345 -0.5
BPHYT_RS03225 -0.1
BPHYT_RS03235 -1.1
BPHYT_RS03825 N.D.
BPHYT_RS08375 N.D.
BPHYT_RS08630 +0.2
BPHYT_RS09560 -0.3
BPHYT_RS10815 N.D.
BPHYT_RS11780 N.D.
BPHYT_RS13545 +0.7
BPHYT_RS14830 -0.1
BPHYT_RS25360 N.D.
BPHYT_RS25695 N.D.
BPHYT_RS27105 +0.3
BPHYT_RS27895 -0.8
BPHYT_RS28620 -0.4
BPHYT_RS35465 +0.9
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
BPHYT_RS03225 -0.1
BPHYT_RS06760 +0.3
BPHYT_RS09560 -0.3
BPHYT_RS13545 +0.7
BPHYT_RS28020 N.D.
BPHYT_RS34155 +0.4
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
BPHYT_RS02230 +0.4
BPHYT_RS03230 +0.7
BPHYT_RS08275 +0.2
BPHYT_RS09150 +3.3
BPHYT_RS09180 -0.1
BPHYT_RS09565 -0.1
BPHYT_RS17345 +0.6
BPHYT_RS21955 -0.2
BPHYT_RS29385 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information