MetaCyc Pathway: serotonin degradation in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes Hans 1000x minerals
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
Pf6N2E2_4632 +0.1
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
Pf6N2E2_1381 +0.0
Pf6N2E2_1764 +0.2
Pf6N2E2_1854 +0.1
Pf6N2E2_1874 N.D.
Pf6N2E2_1878 +0.0
Pf6N2E2_1906 -0.1
Pf6N2E2_1919 +0.3
Pf6N2E2_225 -0.1
Pf6N2E2_3298 +0.1
Pf6N2E2_351 -0.3
Pf6N2E2_3582 +0.1
Pf6N2E2_4383 -0.0
Pf6N2E2_4964 -0.1
Pf6N2E2_4979 +0.2
Pf6N2E2_5476 +0.3
Pf6N2E2_935 -0.0
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
Pf6N2E2_1380 N.D.
Pf6N2E2_1522 +0.4
Pf6N2E2_194 +0.0
Pf6N2E2_2802 +0.1
Pf6N2E2_3044 -1.6
Pf6N2E2_4819 -0.0
Pf6N2E2_5980 -0.1
Pf6N2E2_840 +0.3
Pf6N2E2_999 -0.1
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information