MetaCyc Pathway: serotonin degradation in Burkholderia phytofirmans PsJN

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Reactions and Genes 2-Deoxy-D-Ribose (C)
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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
BPHYT_RS00120 +0.2
BPHYT_RS00395 -0.3
BPHYT_RS05370 -0.4
BPHYT_RS07490 +0.4
BPHYT_RS09900 -0.1
BPHYT_RS17340 +0.1
BPHYT_RS18745 +0.2
BPHYT_RS19710 -0.6
BPHYT_RS20795 -0.5
BPHYT_RS25705 -0.0
BPHYT_RS25810 -6.1
BPHYT_RS27405 -0.7
BPHYT_RS28770 -0.7
BPHYT_RS29875 -0.2
BPHYT_RS30510 +0.1
BPHYT_RS32650 +0.1
BPHYT_RS34980 +0.0
BPHYT_RS35600 +0.3
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
BPHYT_RS00510 -0.6
BPHYT_RS16150 -0.1
BPHYT_RS20205 -0.0
BPHYT_RS24470 -0.0
BPHYT_RS25430 N.D.
BPHYT_RS27390 +0.3
BPHYT_RS28135 -0.1
BPHYT_RS30075 +0.0
BPHYT_RS31305 +0.4
BPHYT_RS31860 N.D.
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information