MetaCyc Pathway: superpathway of cardiolipin biosynthesis (bacteria) in Klebsiella michiganensis M5al

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Reactions and Genes L-tyrosine (N)
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Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) (in reverse):
glycerone phosphate + NAD(P)H + H+→sn-glycerol 3-phosphate + NAD(P)+ (EC 1.1.1.94)
BWI76_RS27210 N.D.
a fatty acyl-[acyl-carrier protein] + phosphate→an acyl phosphate + a soluble [acyl-carrier protein] (EC 2.3.1.274)
No genes
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein]→a 2-lysophosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.15)
BWI76_RS01865 N.D.
BWI76_RS11075 N.D.
an acyl phosphate + sn-glycerol 3-phosphate→a 2-lysophosphatidate + phosphate (EC 2.3.1.275)
No genes
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-[acyl-carrier protein]→a phosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.51)
BWI76_RS00350 +0.3
BWI76_RS24320 N.D.
Phosphatidate cytidylyltransferase:
a phosphatidate + CTP + H+→a CDP-diacylglycerol + diphosphate (EC 2.7.7.41)
BWI76_RS05245 N.D.
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase:
a CDP-diacylglycerol + sn-glycerol 3-phosphate→a phosphatidylglycerophosphate + CMP + H+ (EC 2.7.8.5)
BWI76_RS18325 N.D.
CDP-diacylglycerol--serine O-phosphatidyltransferase:
a CDP-diacylglycerol + L-serine→a phosphatidylserine + CMP + H+ (EC 2.7.8.8)
BWI76_RS21405 N.D.
a CDP-diacylglycerol + a phosphatidylglycerol→a cardiolipin + CMP + H+ (EC 2.7.8.41)
BWI76_RS08850 +0.1
BWI76_RS17205 -2.6
Phosphatidylglycerophosphatase:
a phosphatidylglycerophosphate + H2O→a phosphatidylglycerol + phosphate (EC 3.1.3.27)
BWI76_RS06370 -0.7
BWI76_RS11950 -0.1
BWI76_RS21285 +0.6
Phosphatidylserine decarboxylase:
a phosphatidylserine + H+→a phosphatidylethanolamine + CO2 (EC 4.1.1.65)
BWI76_RS02470 N.D.
2 a phosphatidylglycerol→a cardiolipin + glycerol (EC 2.7.8.41)
BWI76_RS08850 +0.1
BWI76_RS17205 -2.6
a phosphatidylethanolamine + a phosphatidylglycerol→a cardiolipin + ethanolamine (EC 2.7.8.41)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information