| Reactions and Genes | L-Leucine (N) |
|---|
| remove |
Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1) |
| BWI76_RS03690 | -0.1 |
| BWI76_RS06660 | +0.0 |
| BWI76_RS06750 | +0.1 |
| BWI76_RS07560 | +0.1 |
| BWI76_RS07570 | +0.1 |
| BWI76_RS08675 | +0.1 |
| BWI76_RS09870 | -0.1 |
| BWI76_RS10245 | +0.2 |
| BWI76_RS12985 | -0.1 |
| BWI76_RS13400 | +0.4 |
| BWI76_RS20205 | -0.6 |
| BWI76_RS22035 | +0.2 |
| BWI76_RS24235 | -1.6 |
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4) |
| BWI76_RS00790 | -0.2 |
| BWI76_RS01790 | +0.2 |
| BWI76_RS04245 | -0.0 |
L-aspartate oxidase:
L-aspartate + dioxygen→2-iminosuccinate + hydrogen peroxide + H+ (EC 1.4.3.16) |
| BWI76_RS21360 | +0.0 |
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11) |
| BWI76_RS12880 | -0.1 |
| BWI76_RS20385 | -0.2 |
| BWI76_RS26220 | N.D. |
Quinolinate synthase:
2-iminosuccinate + glycerone phosphate→quinolinate + phosphate + 2 H2O (EC 2.5.1.72) |
| BWI76_RS08580 | +0.4 |
| L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7) |
| BWI76_RS00585 | -0.2 |
| BWI76_RS05685 | -0.1 |
| BWI76_RS10255 | +0.3 |
| BWI76_RS15245 | +0.0 |
| BWI76_RS18305 | +0.4 |
| BWI76_RS20905 | N.D. |
| BWI76_RS26315 | +0.1 |
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3) |
| BWI76_RS00790 | -0.2 |
| BWI76_RS04245 | -0.0 |
Nicotinate-nucleotide diphosphorylase (carboxylating) (in reverse):
quinolinate + 2 H+ + 5-phospho-α-D-ribose 1-diphosphate→β-nicotinate D-ribonucleotide + CO2 + diphosphate (EC 2.4.2.19) |
| BWI76_RS04845 | +0.0 |
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39) |
| BWI76_RS04250 | -0.6 |
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46) |
| BWI76_RS01655 | -0.0 |
Nicotinate-nucleotide adenylyltransferase:
β-nicotinate D-ribonucleotide + ATP + H+→nicotinate adenine dinucleotide + diphosphate (EC 2.7.7.18) |
| BWI76_RS08060 | N.D. |
| (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8) |
| BWI76_RS04460 | N.D. |
NAD(+) synthase (glutamine-hydrolyzing):
nicotinate adenine dinucleotide + ATP + L-glutamine + H2O→NAD+ + AMP + L-glutamate + diphosphate + H+ (EC 6.3.5.1) |
| No genes |
NAD(+) synthase:
nicotinate adenine dinucleotide + ammonium + ATP→NAD+ + AMP + diphosphate + H+ (EC 6.3.1.5) |
| BWI76_RS11715 | N.D. |
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48) |
| BWI76_RS00785 | -0.0 |
| BWI76_RS16730 | -0.2 |
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O→N-succinyl-2-amino-6-ketopimelate + coenzyme A (EC 2.3.1.117) |
| BWI76_RS05195 | N.D. |
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1) |
| BWI76_RS04255 | -1.0 |
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13) |
| BWI76_RS16300 | -0.4 |
| BWI76_RS24285 | -0.5 |
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamate→N-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate (EC 2.6.1.17) |
| BWI76_RS09755 | -5.7 |
| BWI76_RS26000 | -0.1 |
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14) |
| BWI76_RS01280 | +0.3 |
| BWI76_RS15390 | -0.0 |
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13) |
| BWI76_RS01685 | +0.1 |
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate (EC 3.5.1.18) |
| BWI76_RS10270 | -0.1 |
| BWI76_RS13530 | +0.0 |
| BWI76_RS14620 | +0.2 |
| BWI76_RS20870 | N.D. |
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate (EC 5.1.1.7) |
| BWI76_RS01200 | +0.6 |
| BWI76_RS18105 | N.D. |
Methionine adenosyltransferase:
L-methionine + ATP + H2O→S-adenosyl-L-methionine + diphosphate + phosphate (EC 2.5.1.6) |
| BWI76_RS24050 | N.D. |
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2 (EC 4.1.1.20) |
| BWI76_RS23360 | -5.0 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information