MetaCyc Pathway: L-arginine biosynthesis I (via L-ornithine) in Klebsiella michiganensis M5al

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Reactions and Genes L-Leucine (N)
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Carbamoyl-phosphate synthase (glutamine-hydrolyzing):
hydrogen carbonate + 2 ATP + L-glutamine + H2O→carbamoyl phosphate + L-glutamate + 2 ADP + 2 H+ + phosphate (EC 6.3.5.5)
BWI76_RS04465 -4.6
BWI76_RS04470 -6.2
Amino-acid N-acetyltransferase:
L-glutamate + acetyl-CoA→N-acetyl-L-glutamate + coenzyme A + H+ (EC 2.3.1.1)
BWI76_RS23220 -4.6
Acetylglutamate kinase:
N-acetyl-L-glutamate + ATP→N-acetylglutamyl-phosphate + ADP (EC 2.7.2.8)
BWI76_RS00850 -5.1
N-acetyl-gamma-glutamyl-phosphate reductase (in reverse):
N-acetylglutamyl-phosphate + NADPH + H+→N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.38)
BWI76_RS00845 -4.0
Acetylornithine transaminase (in reverse):
N-acetyl-L-glutamate 5-semialdehyde + L-glutamate→N-acetyl-L-ornithine + 2-oxoglutarate (EC 2.6.1.11)
BWI76_RS11670 -0.1
BWI76_RS26000 -0.1
Acetylornithine deacetylase:
N-acetyl-L-ornithine + H2O→L-ornithine + acetate (EC 3.5.1.16)
BWI76_RS00840 -2.2
BWI76_RS10270 -0.1
BWI76_RS12865 -0.3
BWI76_RS14620 +0.2
Ornithine carbamoyltransferase:
carbamoyl phosphate + L-ornithine→L-citrulline + H+ + phosphate (EC 2.1.3.3)
BWI76_RS03010 -4.6
Argininosuccinate synthase:
L-citrulline + L-aspartate + ATP→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
BWI76_RS25115 -3.2
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
BWI76_RS00855 -4.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information