MetaCyc Pathway: ketogenesis in Paraburkholderia bryophila 376MFSha3.1

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Reactions and Genes Phenylacetic (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
H281DRAFT_00852 -1.7
H281DRAFT_00857 -0.2
H281DRAFT_00917 -0.0
H281DRAFT_01504 +0.2
H281DRAFT_02089 +0.0
H281DRAFT_04626 -0.4
H281DRAFT_05130 N.D.
H281DRAFT_05518 +0.0
H281DRAFT_05559 +0.0
H281DRAFT_05723 -3.6
H281DRAFT_06132 -0.1
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetyl-CoA + acetoacetate (EC 4.1.3.4)
H281DRAFT_02101 -1.1
H281DRAFT_03571 -0.0
H281DRAFT_03708 +0.1
H281DRAFT_03709 +0.0
H281DRAFT_04763 -0.1
H281DRAFT_04764 -0.1
3-hydroxybutyrate dehydrogenase (in reverse):
acetoacetate + NADH + H+→(R)-3-hydroxybutanoate + NAD+ (EC 1.1.1.30)
H281DRAFT_00644 -0.1
H281DRAFT_03703 +0.4
H281DRAFT_04492 -0.0
H281DRAFT_04976 -0.1
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information