MetaCyc Pathway: glyoxylate assimilation in Klebsiella michiganensis M5al

Add experiment(s):


Reactions and Genes Uridine (N)
remove
Carbonate dehydratase (in reverse):
CO2 + H2O→hydrogen carbonate + H+ (EC 4.2.1.1)
BWI76_RS04960 +0.0
BWI76_RS16635 +0.6
BWI76_RS25560 -0.0
Biotin carboxylase:
hydrogen carbonate + ATP + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine→a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + ADP + H+ + phosphate (EC 6.3.4.14)
BWI76_RS01425 N.D.
BWI76_RS25535 N.D.
BWI76_RS25540 N.D.
a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine + acetyl-CoA→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
BWI76_RS05295 N.D.
BWI76_RS20370 N.D.
malonyl-CoA + NADPH + H+→3-oxopropanoate + coenzyme A + NADP+ (EC 1.2.1.75)
No genes
3-oxopropanoate + NADPH + H+→3-hydroxypropanoate + NADP+ (EC 1.1.1.298)
BWI76_RS10760 -5.0
BWI76_RS15475 +0.4
3-hydroxypropanoate + ATP + coenzyme A→3-hydroxypropanoyl-CoA + AMP + diphosphate (EC 6.2.1.36)
No genes
3-hydroxypropanoyl-CoA→acryloyl-CoA + H2O (EC 4.2.1.116)
No genes
acryloyl-CoA + NADPH + H+→propanoyl-CoA + NADP+ (EC 1.3.1.84)
BWI76_RS12395 +0.0
BWI76_RS25510 +0.3
Malyl-CoA lyase (in reverse):
propanoyl-CoA + glyoxylate→(2R,3S)-β-methylmalyl-CoA (EC 4.1.3.24)
No genes
(2R,3S)-β-methylmalyl-CoA→2-methylfumaryl-CoA + H2O (EC 4.2.1.148)
No genes
2-methylfumaryl-CoA→3-methylfumaryl-CoA (EC 5.4.1.3)
No genes
3-methylfumaryl-CoA + H2O→(3S)-citramalyl-CoA (EC 4.2.1.153)
No genes
Citramalyl-CoA lyase:
(3S)-citramalyl-CoA→acetyl-CoA + pyruvate (EC 4.1.3.25)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information