| Reactions and Genes | 4-Hydroxybenzoic Acid (C) |
|---|
| remove |
| L-quinate + a quinone→3-dehydroquinate + a quinol (EC 1.1.5.8) |
| No genes |
Mandelate racemase (in reverse):
(R)-4-hydroxymandelate→(S)-4-hydroxymandelate (EC 5.1.2.2) |
| H281DRAFT_05472 | +0.1 |
Mandelate racemase (in reverse):
(R)-mandelate→(S)-mandelate (EC 5.1.2.2) |
| H281DRAFT_05472 | +0.1 |
Naphthalene 1,2-dioxygenase:
naphthalene + NADH + dioxygen + H+→(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ (EC 1.14.12.12) |
| No genes |
Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52) |
| H281DRAFT_04144 | -0.4 |
| shikimate + a quinone→3-dehydroshikimate + a quinol (EC 1.1.5.8) |
| No genes |
Toluene dioxygenase:
toluene + NADH + dioxygen + H+→(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+ (EC 1.14.12.11) |
| No genes |
Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase:
(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+→naphthalene-1,2-diol + NADH + H+ (EC 1.3.1.29) |
| No genes |
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10) |
| H281DRAFT_00497 | N.D. |
| H281DRAFT_01677 | -0.7 |
| H281DRAFT_01809 | +0.2 |
| H281DRAFT_03215 | +0.1 |
| H281DRAFT_06285 | +0.2 |
| (S)-4-hydroxymandelate + an electron-transfer quinone→4-hydroxyphenylglyoxylate + an electron-transfer quinol |
| No genes |
Arylformamidase:
N-formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9) |
| H281DRAFT_00939 | +0.8 |
| H281DRAFT_04142 | +0.1 |
(S)-mandelate dehydrogenase:
(S)-mandelate + an oxidized electron carrier→phenylglyoxylate + a reduced two electron carrier (EC 1.1.99.31) |
| No genes |
Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase:
(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+→3-methylcatechol + NADH + H+ (EC 1.3.1.19) |
| No genes |
Benzoylformate decarboxylase:
phenylglyoxylate + H+→benzaldehyde + CO2 (EC 4.1.1.7) |
| No genes |
Catechol 2,3-dioxygenase:
3-methylcatechol + dioxygen→(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H+ (EC 1.13.11.2) |
| No genes |
| 3-dehydroshikimate→protocatechuate + H2O (EC 4.2.1.118) |
| No genes |
Benzoylformate decarboxylase:
4-hydroxyphenylglyoxylate + H+→4-hydroxybenzaldehyde + CO2 (EC 4.1.1.7) |
| No genes |
Kynureninase:
L-kynurenine + H2O→anthranilate + L-alanine + H+ (EC 3.7.1.3) |
| H281DRAFT_04143 | +0.1 |
| naphthalene-1,2-diol + dioxygen→2-hydroxychromene-2-carboxylate + H+ (EC 1.13.11.56) |
| No genes |
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating):
anthranilate + NAD(P)H + dioxygen + 3 H+→catechol + ammonium + CO2 + NAD(P)+ (EC 1.14.12.1) |
| No genes |
| (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O→(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H+ (EC 3.7.1.25) |
| No genes |
Benzaldehyde dehydrogenase (NAD(+)):
benzaldehyde + NAD+ + H2O→benzoate + NADH + 2 H+ (EC 1.2.1.28) |
| No genes |
Benzaldehyde dehydrogenase (NADP(+)):
benzaldehyde + NADP+ + H2O→benzoate + NADPH + 2 H+ (EC 1.2.1.7) |
| No genes |
4-hydroxybenzaldehyde dehydrogenase:
4-hydroxybenzaldehyde + NAD+ + H2O→4-hydroxybenzoate + NADH + 2 H+ (EC 1.2.1.64) |
| No genes |
| 4-hydroxybenzaldehyde + NADP+ + H2O→4-hydroxybenzoate + NADPH + 2 H+ (EC 1.2.1.96) |
| No genes |
| 2-hydroxychromene-2-carboxylate→trans-O-hydroxybenzylidenepyruvate (EC 5.99.1.4) |
| No genes |
4-hydroxybenzoate 3-monooxygenase:
4-hydroxybenzoate + NADPH + dioxygen + H+→protocatechuate + NADP+ + H2O (EC 1.14.13.2) |
| H281DRAFT_01166 | -5.3 |
Benzoate 1,2-dioxygenase:
benzoate + NADH + dioxygen + H+→3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+ (EC 1.14.12.10) |
| H281DRAFT_01075 | +0.6 |
| H281DRAFT_01076 | N.D. |
| H281DRAFT_01077 | +0.4 |
| H281DRAFT_01653 | -0.0 |
| H281DRAFT_01654 | -0.2 |
| H281DRAFT_02475 | -0.0 |
| trans-O-hydroxybenzylidenepyruvate + H2O→salicylaldehyde + pyruvate (EC 4.1.2.45) |
| No genes |
Salicylaldehyde dehydrogenase:
salicylaldehyde + NAD+ + H2O→salicylate + NADH + 2 H+ (EC 1.2.1.65) |
| No genes |
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase:
3,5-cyclohexadiene-1,2-diol-1-carboxylate + NAD+→catechol + CO2 + NADH (EC 1.3.1.25) |
| H281DRAFT_01078 | -0.1 |
| protocatechuate + dioxygen→(2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + H+ |
| No genes |
| (2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde + H+→(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + CO2 (spontaneous) |
| No genes |
Salicylate 1-monooxygenase:
salicylate + NADH + dioxygen + 2 H+→catechol + CO2 + NAD+ + H2O (EC 1.14.13.1) |
| H281DRAFT_02871 | +0.1 |
| H281DRAFT_03387 | -0.1 |
| H281DRAFT_03754 | -0.6 |
Catechol 2,3-dioxygenase:
catechol + dioxygen→(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H+ (EC 1.13.11.2) |
| No genes |
| (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + NAD+ + H2O→(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+ (EC 1.2.1.85) |
| H281DRAFT_03644 | -0.3 |
2-hydroxymuconate-semialdehyde hydrolase:
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O→(2Z)-2-hydroxypenta-2,4-dienoate + formate + H+ (EC 3.7.1.9) |
| H281DRAFT_05418 | +0.0 |
| H281DRAFT_05456 | +0.0 |
| (2Z,4E)-2-hydroxyhexa-2,4-dienedioate→(3E)-2-oxohex-3-enedioate (EC 5.3.2.6) |
| H281DRAFT_03081 | N.D. |
4-oxalocrotonate decarboxylase:
(3E)-2-oxohex-3-enedioate + H+→(2Z)-2-hydroxypenta-2,4-dienoate + CO2 (EC 4.1.1.77) |
| H281DRAFT_01664 | -0.3 |
2-oxopent-4-enoate hydratase (in reverse):
(2Z)-2-hydroxypenta-2,4-dienoate + H2O→(S)-4-hydroxy-2-oxopentanoate (EC 4.2.1.80) |
| H281DRAFT_01663 | N.D. |
| H281DRAFT_03564 | +0.5 |
| H281DRAFT_05231 | +1.9 |
4-hydroxy-2-oxovalerate aldolase:
(S)-4-hydroxy-2-oxopentanoate→acetaldehyde + pyruvate (EC 4.1.3.39) |
| H281DRAFT_01666 | -0.5 |
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+ (EC 1.2.1.10) |
| H281DRAFT_01665 | -1.0 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information