MetaCyc Pathway: pyruvate fermentation to hexanol (engineered) in Marinobacter adhaerens HP15

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Reactions and Genes Tween 20
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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
HP15_3392 +0.1
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
HP15_1009 +0.1
HP15_1233 +0.1
HP15_1513 -1.2
HP15_2344 +0.1
HP15_2423 -0.3
HP15_2695 +0.1
HP15_2996 -1.8
HP15_35 +0.0
HP15_3943 -0.2
HP15_49 -0.0
HP15_5 +0.0
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
HP15_1232 -0.1
HP15_1512 -1.7
HP15_3941 -0.3
HP15_48 +0.1
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
HP15_1141 -0.3
HP15_12 -0.2
HP15_1512 -1.7
HP15_1737 +0.0
HP15_1740 +0.1
HP15_2575 +0.1
HP15_2692 -0.1
HP15_3941 -0.3
HP15_4082 +0.3
HP15_4094 -0.2
HP15_55 +0.0
HP15_864 -0.1
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
crotonyl-CoA + NADH + H+→butanoyl-CoA + NAD+ (EC 1.3.1.44)
HP15_1008 +0.1
HP15_3215 +0.0
HP15_3375 +0.2
HP15_3578 -0.0
HP15_3928 +0.2
HP15_4141 +0.2
HP15_54 +0.0
HP15_56 +0.0
HP15_618 -0.2
HP15_907 +0.0
Acetyl-CoA C-acyltransferase:
acetyl-CoA + butanoyl-CoA→3-oxohexanoyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
HP15_1009 +0.1
HP15_1233 +0.1
HP15_1513 -1.2
HP15_2344 +0.1
HP15_2423 -0.3
HP15_2695 +0.1
HP15_2996 -1.8
HP15_35 +0.0
HP15_3943 -0.2
HP15_49 -0.0
HP15_5 +0.0
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxohexanoyl-CoA + NADH + H+→(S)-3-hydroxyhexanoyl-CoA + NAD+ (EC 1.1.1.35)
HP15_1232 -0.1
HP15_1512 -1.7
HP15_3941 -0.3
HP15_48 +0.1
Long-chain-enoyl-CoA hydratase:
(S)-3-hydroxyhexanoyl-CoA→(2E)-hex-2-enoyl-CoA + H2O (EC 4.2.1.74)
HP15_1141 -0.3
HP15_12 -0.2
HP15_1512 -1.7
HP15_1737 +0.0
HP15_1740 +0.1
HP15_2575 +0.1
HP15_2692 -0.1
HP15_3941 -0.3
HP15_4082 +0.3
HP15_4094 -0.2
HP15_55 +0.0
HP15_864 -0.1
Trans-2-enoyl-CoA reductase (NAD(+)) (in reverse):
(2E)-hex-2-enoyl-CoA + NADH + H+→hexanoyl-CoA + NAD+ (EC 1.3.1.44)
No genes
hexanoyl-CoA + NAD(P)H + H+→1-hexanal + coenzyme A + NAD(P)+
No genes
1-hexanal + NADH + H+→hexan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information