MetaCyc Pathway: UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) in Klebsiella michiganensis M5al

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Reactions and Genes L-Tryptophan (N)
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D-alanine--D-alanine ligase:
2 D-alanine + ATP→D-alanyl-D-alanine + ADP + H+ + phosphate (EC 6.3.2.4)
BWI76_RS04770 +0.5
BWI76_RS06125 +1.1
Glutamate racemase:
L-glutamate→D-glutamate (EC 5.1.1.3)
BWI76_RS00895 N.D.
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate (EC 2.5.1.7)
BWI76_RS25200 N.D.
UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98)
BWI76_RS01420 N.D.
UDP-N-acetylmuramate--L-alanine ligase:
UDP-N-acetyl-α-D-muramate + L-alanine + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanine + ADP + H+ + phosphate (EC 6.3.2.8)
BWI76_RS04765 N.D.
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanine + D-glutamate + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + ADP + H+ + phosphate (EC 6.3.2.9)
BWI76_RS04750 N.D.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + L-lysine + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysine + ADP + H+ + phosphate (EC 6.3.2.7)
No genes
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysine + D-alanyl-D-alanine + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP + H+ + phosphate (EC 6.3.2.10)
BWI76_RS04740 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information