MetaCyc Pathway: (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) in Paraburkholderia bryophila 376MFSha3.1

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Reactions and Genes Phenylacetic (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
H281DRAFT_00852 -1.6
H281DRAFT_00857 -0.1
H281DRAFT_00917 +0.3
H281DRAFT_01504 +0.1
H281DRAFT_02089 -0.1
H281DRAFT_04626 -0.2
H281DRAFT_05130 N.D.
H281DRAFT_05518 -0.1
H281DRAFT_05559 +0.0
H281DRAFT_05723 -5.2
H281DRAFT_06132 +0.1
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
H281DRAFT_00361 -1.8
H281DRAFT_00916 -0.2
H281DRAFT_03517 -0.5
H281DRAFT_04595 -0.9
H281DRAFT_04625 -0.5
H281DRAFT_05521 +0.8
H281DRAFT_06131 -0.2
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
H281DRAFT_00853 -3.5
H281DRAFT_02508 -0.1
(S)-3-hydroxybutanoyl-CoA + H2O→(S)-3-hydroxybutanoate + coenzyme A + H+
No genes
(3R)-3-hydroxybutanoyl-CoA + H2O→(R)-3-hydroxybutanoate + coenzyme A + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information