MetaCyc Pathway: benzoate biosynthesis III (CoA-dependent, non-β-oxidative) in Paraburkholderia bryophila 376MFSha3.1

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Reactions and Genes Phenylacetic (C)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
H281DRAFT_00361 -1.8
H281DRAFT_00373 -0.2
H281DRAFT_00653 +0.7
H281DRAFT_00756 -0.1
H281DRAFT_00916 -0.2
H281DRAFT_01137 N.D.
H281DRAFT_01179 -0.1
H281DRAFT_01187 +0.1
H281DRAFT_01199 -0.1
H281DRAFT_01200 +0.0
H281DRAFT_01276 +0.5
H281DRAFT_01670 +0.2
H281DRAFT_01774 N.D.
H281DRAFT_02068 -0.5
H281DRAFT_02497 -0.7
H281DRAFT_02514 -0.2
H281DRAFT_02515 N.D.
H281DRAFT_02677 +0.0
H281DRAFT_02741 +0.3
H281DRAFT_02927 +0.2
H281DRAFT_03491 N.D.
H281DRAFT_03701 +0.3
H281DRAFT_03739 +0.1
H281DRAFT_03908 -0.0
H281DRAFT_04594 -5.4
H281DRAFT_04595 -0.9
H281DRAFT_04625 -0.5
H281DRAFT_04627 -0.3
H281DRAFT_04744 -0.1
H281DRAFT_05516 +0.2
H281DRAFT_05722 -6.0
H281DRAFT_05725 -5.8
H281DRAFT_05977 -0.1
(S)-3-hydroxy-3-phenylpropanoyl-CoA→benzaldehyde + acetyl-CoA
No genes
Benzaldehyde dehydrogenase (NAD(+)):
benzaldehyde + NAD+ + H2O→benzoate + NADH + 2 H+ (EC 1.2.1.28)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information