MetaCyc Pathway: benzoate biosynthesis I (CoA-dependent, β-oxidative) in Paraburkholderia bryophila 376MFSha3.1

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Reactions and Genes Phenylacetic (C)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
H281DRAFT_00361 -1.8
H281DRAFT_00373 -0.2
H281DRAFT_00653 +0.7
H281DRAFT_00756 -0.1
H281DRAFT_00916 -0.2
H281DRAFT_01137 N.D.
H281DRAFT_01179 -0.1
H281DRAFT_01187 +0.1
H281DRAFT_01199 -0.1
H281DRAFT_01200 +0.0
H281DRAFT_01276 +0.5
H281DRAFT_01670 +0.2
H281DRAFT_01774 N.D.
H281DRAFT_02068 -0.5
H281DRAFT_02497 -0.7
H281DRAFT_02514 -0.2
H281DRAFT_02515 N.D.
H281DRAFT_02677 +0.0
H281DRAFT_02741 +0.3
H281DRAFT_02927 +0.2
H281DRAFT_03491 N.D.
H281DRAFT_03701 +0.3
H281DRAFT_03739 +0.1
H281DRAFT_03908 -0.0
H281DRAFT_04594 -5.4
H281DRAFT_04595 -0.9
H281DRAFT_04625 -0.5
H281DRAFT_04627 -0.3
H281DRAFT_04744 -0.1
H281DRAFT_05516 +0.2
H281DRAFT_05722 -6.0
H281DRAFT_05725 -5.8
H281DRAFT_05977 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
H281DRAFT_00361 -1.8
H281DRAFT_00916 -0.2
H281DRAFT_03517 -0.5
H281DRAFT_04595 -0.9
H281DRAFT_04625 -0.5
H281DRAFT_06131 -0.2
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
H281DRAFT_00852 -1.6
H281DRAFT_00857 -0.1
H281DRAFT_00917 +0.3
H281DRAFT_01504 +0.1
H281DRAFT_02089 -0.1
H281DRAFT_04626 -0.2
H281DRAFT_05130 N.D.
H281DRAFT_05559 +0.0
H281DRAFT_05723 -5.2
H281DRAFT_06132 +0.1
benzoyl-CoA + H2O→benzoate + coenzyme A + H+
No genes
benzoyl-CoA + benzyl alcohol→benzyl benzoate + coenzyme A (EC 2.3.1.196)
No genes
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
H281DRAFT_00369 -0.1
benzyl benzoate + H2O→benzoate + benzyl alcohol + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information