MetaCyc Pathway: superpathway of phenylethylamine degradation in Paraburkholderia bryophila 376MFSha3.1

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Reactions and Genes Phenylacetic (C)
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Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)
No genes
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
No genes
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
H281DRAFT_05720 -5.7
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
H281DRAFT_05857 -3.0
H281DRAFT_05858 -4.3
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
H281DRAFT_02741 +0.3
H281DRAFT_05722 -6.0
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
H281DRAFT_04594 -5.4
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
H281DRAFT_05724 -4.7
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→(2E)-5-carboxy-2-pentenoyl-CoA + acetyl-CoA (EC 2.3.1.223)
H281DRAFT_05723 -5.2
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
H281DRAFT_00361 -1.8
H281DRAFT_00373 -0.2
H281DRAFT_00653 +0.7
H281DRAFT_00756 -0.1
H281DRAFT_00916 -0.2
H281DRAFT_01137 N.D.
H281DRAFT_01179 -0.1
H281DRAFT_01187 +0.1
H281DRAFT_01199 -0.1
H281DRAFT_01200 +0.0
H281DRAFT_01276 +0.5
H281DRAFT_01670 +0.2
H281DRAFT_01774 N.D.
H281DRAFT_02068 -0.5
H281DRAFT_02497 -0.7
H281DRAFT_02514 -0.2
H281DRAFT_02515 N.D.
H281DRAFT_02677 +0.0
H281DRAFT_02741 +0.3
H281DRAFT_02927 +0.2
H281DRAFT_03491 N.D.
H281DRAFT_03701 +0.3
H281DRAFT_03739 +0.1
H281DRAFT_03908 -0.0
H281DRAFT_04594 -5.4
H281DRAFT_04595 -0.9
H281DRAFT_04625 -0.5
H281DRAFT_04627 -0.3
H281DRAFT_04744 -0.1
H281DRAFT_05516 +0.2
H281DRAFT_05722 -6.0
H281DRAFT_05725 -5.8
H281DRAFT_05977 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
H281DRAFT_00361 -1.8
H281DRAFT_00916 -0.2
H281DRAFT_03517 -0.5
H281DRAFT_04595 -0.9
H281DRAFT_04625 -0.5
H281DRAFT_06131 -0.2
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
H281DRAFT_01504 +0.1
H281DRAFT_05723 -5.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information