MetaCyc Pathway: superpathway of L-threonine biosynthesis in Klebsiella michiganensis M5al

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Reactions and Genes L-Leucine (N)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
BWI76_RS03690 +0.3
BWI76_RS06660 -0.0
BWI76_RS06750 +0.2
BWI76_RS07560 +0.1
BWI76_RS07570 -0.2
BWI76_RS08675 +0.0
BWI76_RS09870 -0.4
BWI76_RS10245 -0.4
BWI76_RS12985 +0.4
BWI76_RS13400 +0.5
BWI76_RS20205 -1.6
BWI76_RS22035 +0.0
BWI76_RS24235 -1.7
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
BWI76_RS00790 -0.3
BWI76_RS01790 +0.1
BWI76_RS04245 -0.1
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
BWI76_RS12880 -0.2
BWI76_RS20385 +0.0
BWI76_RS26220 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
BWI76_RS00790 -0.3
BWI76_RS04245 -0.1
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
BWI76_RS04250 -0.3
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
BWI76_RS04255 -1.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information