MetaCyc Pathway: superpathway of fatty acid biosynthesis I (E. coli) in Paraburkholderia bryophila 376MFSha3.1

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Reactions and Genes Malonic (C)
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[Acyl-carrier-protein] S-acetyltransferase:
acetyl-CoA + a soluble [acyl-carrier protein]→an acetyl-[acp] + coenzyme A (EC 2.3.1.38)
No genes
acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
H281DRAFT_00548 N.D.
H281DRAFT_06064 N.D.
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a soluble [acyl-carrier protein]→a malonyl-[acp] + coenzyme A (EC 2.3.1.39)
H281DRAFT_04350 N.D.
H281DRAFT_05276 -1.9
Beta-ketoacyl-acyl-carrier-protein synthase III:
acetyl-CoA + a malonyl-[acp] + H+→an acetoacetyl-[acp] + CO2 + coenzyme A (EC 2.3.1.180)
H281DRAFT_04349 N.D.
Beta-ketoacyl-acyl-carrier-protein synthase II:
an acetyl-[acp] + a malonyl-[acp] + H+→an acetoacetyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
H281DRAFT_03970 +0.2
H281DRAFT_03971 +0.1
H281DRAFT_03974 +0.1
H281DRAFT_04353 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+→a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ (EC 1.1.1.100)
H281DRAFT_00212 N.D.
H281DRAFT_00643 -0.2
H281DRAFT_00677 +0.1
H281DRAFT_00796 +0.2
H281DRAFT_01019 -0.3
H281DRAFT_01131 -0.3
H281DRAFT_01188 +0.0
H281DRAFT_01230 +0.4
H281DRAFT_01561 N.D.
H281DRAFT_01659 -0.0
H281DRAFT_01729 +0.1
H281DRAFT_01811 -0.3
H281DRAFT_02429 -0.3
H281DRAFT_02507 N.D.
H281DRAFT_02561 -0.6
H281DRAFT_02581 -0.9
H281DRAFT_03080 -0.4
H281DRAFT_03241 +0.1
H281DRAFT_03637 -0.0
H281DRAFT_03641 +0.1
H281DRAFT_03712 N.D.
H281DRAFT_03713 -0.3
H281DRAFT_03748 +0.1
H281DRAFT_03856 -0.2
H281DRAFT_03972 -0.1
H281DRAFT_04114 +0.1
H281DRAFT_04145 -0.1
H281DRAFT_04351 N.D.
H281DRAFT_04524 N.D.
H281DRAFT_04910 -0.2
H281DRAFT_05132 -0.4
H281DRAFT_05459 +0.1
H281DRAFT_05476 +0.4
H281DRAFT_05497 -0.1
H281DRAFT_05552 +0.2
H281DRAFT_05556 -0.2
H281DRAFT_05863 -0.3
H281DRAFT_06109 -0.1
H281DRAFT_06110 +0.1
H281DRAFT_06296 +0.1
H281DRAFT_06377 -0.0
H281DRAFT_06505 N.D.
H281DRAFT_06506 +0.1
H281DRAFT_06507 +0.4
H281DRAFT_06578 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyacyl-[acyl-carrier protein]→a trans-2-enoyl-[acyl-carrier protein] + H2O (EC 4.2.1.59)
H281DRAFT_00621 N.D.
H281DRAFT_02426 +0.2
H281DRAFT_06622 N.D.
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
H281DRAFT_00621 N.D.
H281DRAFT_02426 +0.2
H281DRAFT_06622 N.D.
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a (2E)-dec-2-enoyl-[acp]→a (3Z)-dec-3-enoyl-[acp] (EC 5.3.3.14)
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADH + H+→a 2,3,4-saturated fatty acyl-[acp] + NAD+ (EC 1.3.1.9)
H281DRAFT_00003 -0.1
H281DRAFT_02163 -0.1
Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) (in reverse):
a trans-2-enoyl-[acyl-carrier protein] + NADPH + H+→a 2,3,4-saturated fatty acyl-[acp] + NADP+ (EC 1.3.1.10; 1.3.1.104; 1.3.1.39)
H281DRAFT_00677 +0.1
H281DRAFT_01425 N.D.
H281DRAFT_05983 +0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a 2,3,4-saturated fatty acyl-[acp] + a malonyl-[acp] + H+→a 3-oxoacyl-[acyl-carrier protein] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
H281DRAFT_03970 +0.2
H281DRAFT_03971 +0.1
H281DRAFT_03974 +0.1
H281DRAFT_04353 N.D.
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (3Z)-dec-3-enoyl-[acp] + a malonyl-[acp] + H+→a (5Z)-3-oxododec-5-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
H281DRAFT_03970 +0.2
H281DRAFT_03971 +0.1
H281DRAFT_03974 +0.1
H281DRAFT_04353 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (5Z)-3-oxododec-5-enoyl-[acp] + NADPH + H+→a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp] + NADP+ (EC 1.1.1.100)
H281DRAFT_00212 N.D.
H281DRAFT_00643 -0.2
H281DRAFT_00677 +0.1
H281DRAFT_00796 +0.2
H281DRAFT_01019 -0.3
H281DRAFT_01131 -0.3
H281DRAFT_01188 +0.0
H281DRAFT_01230 +0.4
H281DRAFT_01561 N.D.
H281DRAFT_01659 -0.0
H281DRAFT_01729 +0.1
H281DRAFT_01811 -0.3
H281DRAFT_02429 -0.3
H281DRAFT_02507 N.D.
H281DRAFT_02561 -0.6
H281DRAFT_02581 -0.9
H281DRAFT_03080 -0.4
H281DRAFT_03241 +0.1
H281DRAFT_03637 -0.0
H281DRAFT_03641 +0.1
H281DRAFT_03712 N.D.
H281DRAFT_03713 -0.3
H281DRAFT_03748 +0.1
H281DRAFT_03856 -0.2
H281DRAFT_03972 -0.1
H281DRAFT_04114 +0.1
H281DRAFT_04145 -0.1
H281DRAFT_04351 N.D.
H281DRAFT_04524 N.D.
H281DRAFT_04910 -0.2
H281DRAFT_05132 -0.4
H281DRAFT_05459 +0.1
H281DRAFT_05476 +0.4
H281DRAFT_05497 -0.1
H281DRAFT_05552 +0.2
H281DRAFT_05556 -0.2
H281DRAFT_05863 -0.3
H281DRAFT_06109 -0.1
H281DRAFT_06110 +0.1
H281DRAFT_06296 +0.1
H281DRAFT_06377 -0.0
H281DRAFT_06505 N.D.
H281DRAFT_06506 +0.1
H281DRAFT_06507 +0.4
H281DRAFT_06578 +0.2
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp]→a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + H2O (EC 4.2.1.59)
H281DRAFT_00621 N.D.
H281DRAFT_02426 +0.2
H281DRAFT_06622 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + NADH + H+→a (5Z)-dodec-5-enoyl-[acp] + NAD+ (EC 1.3.1.9)
H281DRAFT_00003 -0.1
H281DRAFT_02163 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information