MetaCyc Pathway: superpathway of cardiolipin biosynthesis (bacteria) in Pseudomonas stutzeri RCH2

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Reactions and Genes Def Chloride 400 mM
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Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) (in reverse):
glycerone phosphate + NAD(P)H + H+→sn-glycerol 3-phosphate + NAD(P)+ (EC 1.1.1.94)
Psest_2471 N.D.
a fatty acyl-[acyl-carrier protein] + phosphate→an acyl phosphate + a soluble [acyl-carrier protein] (EC 2.3.1.274)
No genes
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein]→a 2-lysophosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.15)
Psest_1608 -0.1
Psest_1686 -0.2
Psest_3678 -0.2
an acyl phosphate + sn-glycerol 3-phosphate→a 2-lysophosphatidate + phosphate (EC 2.3.1.275)
No genes
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-[acyl-carrier protein]→a phosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.51)
Psest_1531 -0.3
Psest_3199 -0.0
Psest_0008 N.D.
Phosphatidate cytidylyltransferase:
a phosphatidate + CTP + H+→a CDP-diacylglycerol + diphosphate (EC 2.7.7.41)
Psest_2837 N.D.
Psest_3291 +0.0
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase:
a CDP-diacylglycerol + sn-glycerol 3-phosphate→a phosphatidylglycerophosphate + CMP + H+ (EC 2.7.8.5)
Psest_2258 N.D.
CDP-diacylglycerol--serine O-phosphatidyltransferase:
a CDP-diacylglycerol + L-serine→a phosphatidylserine + CMP + H+ (EC 2.7.8.8)
Psest_1039 N.D.
a CDP-diacylglycerol + a phosphatidylglycerol→a cardiolipin + CMP + H+ (EC 2.7.8.41)
Psest_2160 -0.2
Psest_3196 -2.0
Psest_3796 +0.1
Phosphatidylglycerophosphatase:
a phosphatidylglycerophosphate + H2O→a phosphatidylglycerol + phosphate (EC 3.1.3.27)
Psest_3546 +0.3
Phosphatidylserine decarboxylase:
a phosphatidylserine + H+→a phosphatidylethanolamine + CO2 (EC 4.1.1.65)
Psest_0493 N.D.
2 a phosphatidylglycerol→a cardiolipin + glycerol (EC 2.7.8.41)
No genes
a phosphatidylethanolamine + a phosphatidylglycerol→a cardiolipin + ethanolamine (EC 2.7.8.41)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information