MetaCyc Pathway: ectoine biosynthesis in Pseudomonas stutzeri RCH2

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Reactions and Genes Def Chloride 400 mM
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
Psest_2988 +1.9
Psest_4094 -0.2
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
Psest_1328 N.D.
Psest_2587 +0.1
Psest_2588 N.D.
Diaminobutyrate--2-oxoglutarate transaminase (in reverse):
L-aspartate 4-semialdehyde + L-glutamate→L-2,4-diaminobutanoate + 2-oxoglutarate (EC 2.6.1.76)
Psest_4091 -1.0
Diaminobutyrate acetyltransferase:
L-2,4-diaminobutanoate + acetyl-CoA→(2S)-4-acetamido-2-aminobutanoate + coenzyme A + H+ (EC 2.3.1.178)
Psest_4090 -1.6
Ectoine synthase:
(2S)-4-acetamido-2-aminobutanoate→ectoine + H2O (EC 4.2.1.108)
Psest_4092 -1.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information