MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Pseudomonas fluorescens FW300-N2C3

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Reactions and Genes L-Phenylalanine (N)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
AO356_00370 +0.1
AO356_03120 -0.1
AO356_03200 -0.1
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
AO356_09385 N.D.
AO356_23655 +0.1
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
AO356_05940 N.D.
AO356_08185 N.D.
AO356_15595 -0.1
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
AO356_01830 -0.1
AO356_11315 -2.1
AO356_15590 +0.3
AO356_27475 -0.1
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
AO356_09390 N.D.
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
AO356_03455 -0.2
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
AO356_19540 N.D.
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
AO356_03465 N.D.
AO356_09710 +0.1
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
AO356_03465 N.D.
AO356_25650 +0.0
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
AO356_01275 +0.0
AO356_03090 -0.0
AO356_03460 +0.2
AO356_03985 -2.1
AO356_06565 +0.1
AO356_06960 -2.9
AO356_12070 -0.0
AO356_12595 -0.0
AO356_16875 -1.3
AO356_19495 -0.0
AO356_19865 -0.0
AO356_19905 -0.1
AO356_20345 +0.4
AO356_21330 -0.0
AO356_22880 +0.0
AO356_24005 +0.2
AO356_24115 +0.0
AO356_24720 -0.3
AO356_24975 +0.1
AO356_25355 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information