MetaCyc Pathway: superpathway of phenylethylamine degradation in Pseudomonas fluorescens FW300-N2C3

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Reactions and Genes Carnitine Hydrochloride (C)
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Primary-amine oxidase:
2-phenylethylamine + dioxygen + H2O→phenylacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.21; 1.4.3.4)
AO356_13575 -0.0
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
AO356_15225 -0.2
AO356_25485 -0.3
AO356_28025 -4.0
AO356_28685 -0.4
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
No genes
phenylacetyl-CoA + NADPH + dioxygen + H+→2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP+ + H2O (EC 1.14.13.149)
No genes
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA→2-oxepin-2(3H)-ylideneacetyl-CoA (EC 5.3.3.18)
No genes
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O→3-oxo-5,6-didehydrosuberyl-CoA semialdehyde (EC 3.3.2.12)
No genes
3-oxo-5,6-didehydrosuberyl-CoA semialdehyde + NADP+ + H2O→3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H+ (EC 1.2.1.91)
No genes
3-oxo-5,6-didehydrosuberyl-CoA + coenzyme A→(2E)-5-carboxy-2-pentenoyl-CoA + acetyl-CoA (EC 2.3.1.223)
No genes
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
AO356_02330 N.D.
AO356_04640 -0.3
AO356_10120 +0.0
AO356_12440 +0.0
AO356_17825 +0.3
AO356_20400 +0.1
AO356_20420 N.D.
AO356_25890 -0.1
AO356_26360 -1.6
AO356_26370 +0.1
AO356_26645 -0.3
AO356_27920 +0.3
AO356_30295 -0.2
AO356_30355 +0.0
AO356_30360 +0.0
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
AO356_02330 N.D.
AO356_10120 +0.0
AO356_13845 -4.1
AO356_20400 +0.1
AO356_30295 -0.2
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
AO356_04930 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information