MetaCyc Pathway: 2-oxoglutarate decarboxylation to succinyl-CoA in Pseudomonas fluorescens FW300-N2C3

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Reactions and Genes L-Leucine (C)
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a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2-oxoglutarate + H+→a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine + CO2 (EC 1.2.1.105; 1.2.4.2)
AO356_19695 N.D.
a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine + coenzyme A→a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + succinyl-CoA (EC 1.2.1.105; 2.3.1.61)
AO356_19700 N.D.
a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+→a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (EC 1.2.1.105; 1.8.1.4)
AO356_11880 -0.1
AO356_19705 N.D.
AO356_22975 -2.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information