MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pseudomonas fluorescens FW300-N2C3

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Reactions and Genes L-Isoleucine (C)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
AO356_01275 +0.4
AO356_03090 -0.2
AO356_03985 +0.0
AO356_06565 -0.1
AO356_12070 +0.0
AO356_12595 +0.3
AO356_16875 +0.2
AO356_19495 +0.0
AO356_19865 +0.1
AO356_19905 +0.1
AO356_20345 -3.6
AO356_22880 +0.0
AO356_24005 -0.2
AO356_24115 -0.0
AO356_24720 +0.0
AO356_24975 -0.1
AO356_25355 +0.0
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
AO356_18775 +0.1
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
AO356_04970 +0.3
AO356_21420 N.D.
AO356_21425 -0.2
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
AO356_06375 N.D.
AO356_15140 -0.5
AO356_27140 +0.1
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
AO356_11475 N.D.
AO356_20835 +0.3
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
AO356_06370 N.D.
AO356_15130 -0.3
AO356_16855 -0.1
AO356_27150 +0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information