MetaCyc Pathway: palmitate biosynthesis II (type II fatty acid synthase) in Sphingomonas koreensis DSMZ 15582

Add experiment(s):


Reactions and Genes L-Glutamine (N)
remove
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H+→a (3R)-3-hydroxybutanoyl-[acp] + NADP+ (EC 1.1.1.100)
Ga0059261_0364 N.D.
Ga0059261_0812 +0.0
Ga0059261_0843 -0.0
Ga0059261_0844 -0.2
Ga0059261_0867 -0.2
Ga0059261_1325 -0.2
Ga0059261_1787 -0.0
Ga0059261_1900 -0.2
Ga0059261_1968 -0.2
Ga0059261_2637 +0.0
Ga0059261_2655 -0.0
Ga0059261_2665 +0.1
Ga0059261_2801 -0.3
Ga0059261_2802 -0.1
Ga0059261_2830 -0.2
Ga0059261_2841 -0.0
Ga0059261_2843 +0.1
Ga0059261_2846 -0.0
Ga0059261_2853 +0.1
Ga0059261_2871 -0.1
Ga0059261_2872 -0.0
Ga0059261_2882 -0.0
Ga0059261_2906 +0.1
Ga0059261_4067 -4.4
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Ga0059261_0178 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADH + H+→a butanoyl-[acp] + NAD+ (EC 1.3.1.9)
Ga0059261_2468 N.D.
Ga0059261_2760 -0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a butanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Ga0059261_0362 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexanoyl-[acp] + NADP+ (EC 1.1.1.100)
Ga0059261_0364 N.D.
Ga0059261_0812 +0.0
Ga0059261_0843 -0.0
Ga0059261_0844 -0.2
Ga0059261_0867 -0.2
Ga0059261_1325 -0.2
Ga0059261_1787 -0.0
Ga0059261_1900 -0.2
Ga0059261_1968 -0.2
Ga0059261_2637 +0.0
Ga0059261_2655 -0.0
Ga0059261_2665 +0.1
Ga0059261_2801 -0.3
Ga0059261_2802 -0.1
Ga0059261_2830 -0.2
Ga0059261_2841 -0.0
Ga0059261_2843 +0.1
Ga0059261_2846 -0.0
Ga0059261_2853 +0.1
Ga0059261_2871 -0.1
Ga0059261_2872 -0.0
Ga0059261_2882 -0.0
Ga0059261_2906 +0.1
Ga0059261_4067 -4.4
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Ga0059261_0178 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADH + H+→a hexanoyl-[acp] + NAD+ (EC 1.3.1.9)
Ga0059261_2468 N.D.
Ga0059261_2760 -0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a hexanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Ga0059261_0362 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctanoyl-[acp] + NADP+ (EC 1.1.1.100)
Ga0059261_0364 N.D.
Ga0059261_0812 +0.0
Ga0059261_0843 -0.0
Ga0059261_0844 -0.2
Ga0059261_0867 -0.2
Ga0059261_1325 -0.2
Ga0059261_1787 -0.0
Ga0059261_1900 -0.2
Ga0059261_1968 -0.2
Ga0059261_2637 +0.0
Ga0059261_2655 -0.0
Ga0059261_2665 +0.1
Ga0059261_2801 -0.3
Ga0059261_2802 -0.1
Ga0059261_2830 -0.2
Ga0059261_2841 -0.0
Ga0059261_2843 +0.1
Ga0059261_2846 -0.0
Ga0059261_2853 +0.1
Ga0059261_2871 -0.1
Ga0059261_2872 -0.0
Ga0059261_2882 -0.0
Ga0059261_2906 +0.1
Ga0059261_4067 -4.4
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Ga0059261_0178 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADH + H+→an octanoyl-[acp] + NAD+ (EC 1.3.1.9)
Ga0059261_2468 N.D.
Ga0059261_2760 -0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
an octanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxodecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Ga0059261_0362 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydecanoyl-[acp] + NADP+ (EC 1.1.1.100)
Ga0059261_0364 N.D.
Ga0059261_0812 +0.0
Ga0059261_0843 -0.0
Ga0059261_0844 -0.2
Ga0059261_0867 -0.2
Ga0059261_1325 -0.2
Ga0059261_1787 -0.0
Ga0059261_1900 -0.2
Ga0059261_1968 -0.2
Ga0059261_2637 +0.0
Ga0059261_2655 -0.0
Ga0059261_2665 +0.1
Ga0059261_2801 -0.3
Ga0059261_2802 -0.1
Ga0059261_2830 -0.2
Ga0059261_2841 -0.0
Ga0059261_2843 +0.1
Ga0059261_2846 -0.0
Ga0059261_2853 +0.1
Ga0059261_2871 -0.1
Ga0059261_2872 -0.0
Ga0059261_2882 -0.0
Ga0059261_2906 +0.1
Ga0059261_4067 -4.4
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Ga0059261_0178 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dec-2-enoyl-[acp] + NADH + H+→a decanoyl-[acp] + NAD+ (EC 1.3.1.9)
Ga0059261_2468 N.D.
Ga0059261_2760 -0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a decanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxododecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Ga0059261_0362 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxododecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydodecanoyl-[acp] + NADP+ (EC 1.1.1.100)
Ga0059261_0364 N.D.
Ga0059261_0812 +0.0
Ga0059261_0843 -0.0
Ga0059261_0844 -0.2
Ga0059261_0867 -0.2
Ga0059261_1325 -0.2
Ga0059261_1787 -0.0
Ga0059261_1900 -0.2
Ga0059261_1968 -0.2
Ga0059261_2637 +0.0
Ga0059261_2655 -0.0
Ga0059261_2665 +0.1
Ga0059261_2801 -0.3
Ga0059261_2802 -0.1
Ga0059261_2830 -0.2
Ga0059261_2841 -0.0
Ga0059261_2843 +0.1
Ga0059261_2846 -0.0
Ga0059261_2853 +0.1
Ga0059261_2871 -0.1
Ga0059261_2872 -0.0
Ga0059261_2882 -0.0
Ga0059261_2906 +0.1
Ga0059261_4067 -4.4
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Ga0059261_0178 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dodec-2-enoyl-[acp] + NADH + H+→a dodecanoyl-[acp] + NAD+ (EC 1.3.1.9)
Ga0059261_2468 N.D.
Ga0059261_2760 -0.0
Dodecanoyl-[acyl-carrier-protein] hydrolase:
a dodecanoyl-[acp][nil] + H2O[nil]→laurate[nil] + a soluble [acyl-carrier protein][nil] + H+[nil] (EC 3.1.2.21)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a dodecanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxotetradecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Ga0059261_0362 N.D.
Butyrate--CoA ligase:
laurate + ATP + coenzyme A→lauroyl-CoA + AMP + diphosphate (EC 6.2.1.2; 6.2.1.3)
Ga0059261_0771 -0.1
Ga0059261_1004 -0.1
Ga0059261_1467 -1.9
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP+ (EC 1.1.1.100)
Ga0059261_0364 N.D.
Ga0059261_0812 +0.0
Ga0059261_0843 -0.0
Ga0059261_0844 -0.2
Ga0059261_0867 -0.2
Ga0059261_1325 -0.2
Ga0059261_1787 -0.0
Ga0059261_1900 -0.2
Ga0059261_1968 -0.2
Ga0059261_2637 +0.0
Ga0059261_2655 -0.0
Ga0059261_2665 +0.1
Ga0059261_2801 -0.3
Ga0059261_2802 -0.1
Ga0059261_2830 -0.2
Ga0059261_2841 -0.0
Ga0059261_2843 +0.1
Ga0059261_2846 -0.0
Ga0059261_2853 +0.1
Ga0059261_2871 -0.1
Ga0059261_2872 -0.0
Ga0059261_2882 -0.0
Ga0059261_2906 +0.1
Ga0059261_4067 -4.4
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Ga0059261_0178 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADH + H+→a myristoyl-[acp] + NAD+ (EC 1.3.1.9)
Ga0059261_2468 N.D.
Ga0059261_2760 -0.0
Beta-ketoacyl-acyl-carrier-protein synthase II:
a myristoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
Ga0059261_0362 N.D.
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexadecanoyl-[acp] + NADP+ (EC 1.1.1.100)
Ga0059261_0364 N.D.
Ga0059261_0812 +0.0
Ga0059261_0843 -0.0
Ga0059261_0844 -0.2
Ga0059261_0867 -0.2
Ga0059261_1325 -0.2
Ga0059261_1787 -0.0
Ga0059261_1900 -0.2
Ga0059261_1968 -0.2
Ga0059261_2637 +0.0
Ga0059261_2655 -0.0
Ga0059261_2665 +0.1
Ga0059261_2801 -0.3
Ga0059261_2802 -0.1
Ga0059261_2830 -0.2
Ga0059261_2841 -0.0
Ga0059261_2843 +0.1
Ga0059261_2846 -0.0
Ga0059261_2853 +0.1
Ga0059261_2871 -0.1
Ga0059261_2872 -0.0
Ga0059261_2882 -0.0
Ga0059261_2906 +0.1
Ga0059261_4067 -4.4
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexadecanoyl-[acp]→a (2E)-hexadec-2-enoyl-[acp] + H2O (EC 4.2.1.59)
Ga0059261_0178 N.D.
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hexadec-2-enoyl-[acp] + NADH + H+→a palmitoyl-[acp] + NAD+ (EC 1.3.1.9)
Ga0059261_2468 N.D.
Ga0059261_2760 -0.0
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoyl-[acp] + H2O→palmitate + a soluble [acyl-carrier protein] + H+ (EC 3.1.2.14)
No genes
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
Ga0059261_0771 -0.1
Ga0059261_1004 -0.1
Ga0059261_1467 -1.9

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information