MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pseudomonas fluorescens FW300-N1B4

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Reactions and Genes L-Serine (N)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
Pf1N1B4_160 -0.0
Pf1N1B4_2018 +0.0
Pf1N1B4_2139 +0.0
Pf1N1B4_261 +0.0
Pf1N1B4_3564 -0.1
Pf1N1B4_3771 -0.3
Pf1N1B4_386 -1.2
Pf1N1B4_4186 -0.1
Pf1N1B4_4425 -0.2
Pf1N1B4_4646 -0.1
Pf1N1B4_4672 N.D.
Pf1N1B4_4996 +0.0
Pf1N1B4_5070 +0.1
Pf1N1B4_510 -0.3
Pf1N1B4_5999 +0.2
Pf1N1B4_818 -0.0
Pf1N1B4_849 +0.1
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
Pf1N1B4_3451 -1.2
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
Pf1N1B4_10 -0.0
Pf1N1B4_11 N.D.
Pf1N1B4_3225 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
Pf1N1B4_3013 N.D.
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
Pf1N1B4_1873 N.D.
Pf1N1B4_3813 +0.4
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
Pf1N1B4_3014 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information