MetaCyc Pathway: superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation in Pseudomonas fluorescens FW300-N1B4

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Reactions and Genes L-Serine (N)
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Arginine decarboxylase:
L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
Pf1N1B4_1136 -0.0
Pf1N1B4_1296 +0.2
Pf1N1B4_4600 +0.3
Agmatinase:
agmatine + H2O→putrescine + urea (EC 3.5.3.11)
Pf1N1B4_4717 +0.6
Pf1N1B4_525 -0.0
Putrescine aminotransferase:
putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
No genes
Glutamate--putrescine ligase:
putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
Pf1N1B4_2254 +0.3
Pf1N1B4_4354 +0.1
Aminobutyraldehyde dehydrogenase:
4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
Pf1N1B4_171 -0.0
Pf1N1B4_2132 +0.4
Pf1N1B4_2673 -0.0
Pf1N1B4_3024 +0.0
Pf1N1B4_3029 +0.2
Pf1N1B4_4244 +0.0
Pf1N1B4_4264 -0.1
Pf1N1B4_4355 +0.1
Pf1N1B4_4502 N.D.
Pf1N1B4_4920 -0.0
Pf1N1B4_695 +0.4
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
Pf1N1B4_4356 +0.1
Pf1N1B4_4824 -0.0
Pf1N1B4_6047 +0.0
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
No genes
Gamma-glutamyl-gamma-aminobutyrate hydrolase:
4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
Pf1N1B4_2255 -0.3
Pf1N1B4_4353 N.D.
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
Pf1N1B4_1045 +0.1
Pf1N1B4_1663 +0.1
Pf1N1B4_1733 -2.8
Pf1N1B4_4910 +0.0
Succinate-semialdehyde dehydrogenase:
succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
Pf1N1B4_1220 +0.2
Pf1N1B4_5616 +0.2
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
Pf1N1B4_4931 +0.7

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information