MetaCyc Pathway: superpathway of (R,R)-butanediol biosynthesis in Klebsiella michiganensis M5al

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Reactions and Genes D-Lactate (C)
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Acetolactate synthase:
2 pyruvate + H+→(S)-2-acetolactate + CO2 (EC 2.2.1.6)
BWI76_RS00960 -1.1
BWI76_RS00965 -2.0
BWI76_RS04695 +0.0
BWI76_RS04700 +0.1
BWI76_RS12900 -0.3
BWI76_RS16750 +0.2
BWI76_RS27810 -1.1
BWI76_RS27815 -2.7
Acetolactate decarboxylase:
(S)-2-acetolactate + H+→CO2 + (R)-acetoin (EC 4.1.1.5)
BWI76_RS16745 -0.1
(S)-2-acetolactate + an oxidized electron carrier + H+→CO2 + diacetyl + a reduced two electron carrier (spontaneous)
No genes
diacetyl + NADH + H+→(R)-acetoin + NAD+ (EC 1.1.1.303)
BWI76_RS16755 -0.0
BWI76_RS23630 +0.1
(R,R)-butanediol dehydrogenase (in reverse):
(R)-acetoin + NADH + H+→(R,R)-2,3-butanediol + NAD+ (EC 1.1.1.4)
BWI76_RS16755 -0.0
BWI76_RS23630 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information