MetaCyc Pathway: superpathway of coenzyme A biosynthesis II (plants) in Pseudomonas fluorescens FW300-N2E3

Reactions and Genes	Uridine (N)
3-methyl-2-oxobutanoate hydroxymethyltransferase: 3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
AO353_14385	-0.2
AO353_14695	+0.1
AO353_15155	-0.1
Propionate--CoA ligase: propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
AO353_03060	-0.1
AO353_14365	-0.0
2-dehydropantoate 2-reductase (in reverse): 2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
AO353_03645	+0.0
AO353_14505	-3.7
AO353_19045	+0.2
propanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→acryloyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
AO353_12805	-0.1
AO353_25680	+0.0
acryloyl-CoA + H2O→3-hydroxypropanoyl-CoA (EC 4.2.1.116)
AO353_25675	N.D.
3-hydroxyisobutyryl-CoA hydrolase: 3-hydroxypropanoyl-CoA + H2O→3-hydroxypropanoate + coenzyme A + H+ (EC 3.1.2.4)
AO353_25665	-0.1
3-hydroxypropionate dehydrogenase: 3-hydroxypropanoate + NAD+→3-oxopropanoate + NADH + H+ (EC 1.1.1.59)
No genes
Beta-alanine--pyruvate transaminase: 3-oxopropanoate + L-alanine→β-alanine + pyruvate (EC 2.6.1.18)
AO353_06085	-3.8
AO353_08585	+0.1
AO353_15040	+0.1
Pantoate--beta-alanine ligase: β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
AO353_08630	-0.2
AO353_14380	-0.5
Pantothenate kinase: (R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
AO353_07100	N.D.
AO353_08605	-0.1

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information