MetaCyc Pathway: peptidoglycan recycling I in Klebsiella michiganensis M5al

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Reactions and Genes D-Glucosamine Hydrochloride (C)
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a mature peptidoglycan (meso-DAP containing)→a mature peptidoglycan (meso-DAP containing) + GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala (EC 4.2.2.f)
BWI76_RS04185 -0.0
BWI76_RS05435 +0.2
BWI76_RS17715 +0.1
BWI76_RS21275 -0.2
BWI76_RS22210 +0.1
BWI76_RS22980 +0.2
BWI76_RS24165 +0.1
GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[out] + H+[out]→GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[in] + H+[in]
BWI76_RS06500 -0.8
N-acetylmuramoyl-L-alanine amidase:
GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala + H2ON-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine
(EC 3.5.1.28)
BWI76_RS02520 +0.2
BWI76_RS04850 -1.1
BWI76_RS09535 -0.0
BWI76_RS20735 +0.1
BWI76_RS23215 -0.1
Beta-N-acetylhexosaminidase:
N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + H2O→1,6-anhydro-N-acetyl-β-D-muramate + N-acetyl-D-glucosamine
(EC 3.2.1.52)
BWI76_RS11165 -1.0
Muramoyltetrapeptide carboxypeptidase:
L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine + H2O→L-alanyl-γ-D-glutamyl-meso-diaminopimelate + D-alanine
(EC 3.4.17.13)
BWI76_RS17720 -1.1
1,6-anhydro-N-acetyl-β-D-muramate + ATP + H2ON-acetyl-D-muramate 6-phosphate + ADP + H+ (EC 2.7.1.170)
BWI76_RS16420 -0.1
N-acetyl-D-muramate 6-phosphate + H2ON-acetyl-D-glucosamine 6-phosphate + (R)-lactate (EC 4.2.1.126)
BWI76_RS27710 -1.0
N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H2O→D-glucosamine 6-phosphate + acetate
(EC 3.5.1.25)
BWI76_RS08210 +0.9
Phosphoglucosamine mutase:
D-glucosamine 6-phosphate→α-D-glucosamine 1-phosphate
(EC 5.4.2.10)
BWI76_RS25130 N.D.
Glucosamine-1-phosphate N-acetyltransferase:
α-D-glucosamine 1-phosphate + acetyl-CoAN-acetyl-α-D-glucosamine 1-phosphate + coenzyme A + H+
(EC 2.3.1.157)
BWI76_RS00170 N.D.
UDP-N-acetylglucosamine diphosphorylase:
N-acetyl-α-D-glucosamine 1-phosphate + H+ + UTP→UDP-N-acetyl-α-D-glucosamine + diphosphate
(EC 2.7.7.23)
BWI76_RS00170 N.D.
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate
(EC 2.5.1.7)
BWI76_RS25200 N.D.
UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98)
BWI76_RS01420 N.D.
L-alanyl-γ-D-glutamyl-meso-diaminopimelate + UDP-N-acetyl-α-D-muramate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.45)
BWI76_RS02820 -0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information