MetaCyc Pathway: ketogenesis in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes butyrate (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
AO353_00505 -0.5
AO353_01065 +3.0
AO353_01160 +0.1
AO353_05785 +0.0
AO353_13880 +0.1
AO353_17205 -1.2
AO353_25685 -2.7
AO353_27530 -2.4
AO353_27945 -0.2
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA lyase:
(S)-3-hydroxy-3-methylglutaryl-CoA→acetyl-CoA + acetoacetate (EC 4.1.3.4)
AO353_20365 N.D.
3-hydroxybutyrate dehydrogenase (in reverse):
acetoacetate + NADH + H+→(R)-3-hydroxybutanoate + NAD+ (EC 1.1.1.30)
AO353_21770 -0.0
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information