MetaCyc Pathway: (2S)-ethylmalonyl-CoA biosynthesis in Pseudomonas fluorescens FW300-N2E3

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Reactions and Genes butyrate (C)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
AO353_00505 -0.5
AO353_01065 +3.0
AO353_01160 +0.1
AO353_05785 +0.0
AO353_13880 +0.1
AO353_17205 -1.2
AO353_25685 -2.7
AO353_27530 -2.4
AO353_27945 -0.2
Acetoacetyl-CoA reductase (in reverse):
acetoacetyl-CoA + NADPH + H+→(3R)-3-hydroxybutanoyl-CoA + NADP+ (EC 1.1.1.36)
AO353_01060 +3.5
3-hydroxybutyryl-CoA dehydratase:
(3R)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.55)
No genes
crotonyl-CoA + CO2 + NADPH→(2S)-ethylmalonyl-CoA + NADP+ (EC 1.3.1.85)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information